gene

PER3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PER3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

38Outgoing

19Incoming

0Experiments

0Debates

Summary

Period Circadian Regulator 3 - core circadian clock gene

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🧬 Gene Info

Gene Symbol	PER3
Full Name	Period Circadian Regulator 3
Chromosome	1p36.23
Function	The PER3 gene encodes the Period Circadian Regulator 3 protein, a core component of the mammalian circadian clock.
Molecular Weight	121 kDa
Pathways	ubiquitin-proteasome
UniProt ID	Q8WY51
NCBI Gene ID	8863
Ensembl ID	ENSG00000149257
OMIM	604352
GeneCards	PER3
Human Protein Atlas	PER3
Associated Diseases	ALS, autism spectrum disorder
Interactions	HCRTR2, PER2
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PER3 — AlphaFold Q8WY51 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PER3 Gene

gene · 805 words

→

PER3 Protein

protein · 704 words

→

Pathway Diagram

graph TD
    PER3["PER3"]
    Carcinoma{"Carcinoma"}
    PER3 -->|"expressed in"| Carcinoma
    Cancer{"Cancer"}
    PER3 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    PER3 -->|"expressed in"| Tumor
    PER1["PER1"]
    PER3 -->|"expressed in"| PER1
    CRY1["CRY1"]
    PER3 -->|"expressed in"| CRY1
    CRY2["CRY2"]
    PER3 -->|"expressed in"| CRY2
    PER2["PER2"]
    PER3 -->|"expressed in"| PER2
    CANCER["CANCER"]
    PER3 -->|"expressed in"| CANCER
    SIRT1["SIRT1"]
    PER3 -->|"expressed in"| SIRT1
    CLOCK["CLOCK"]
    PER3 -->|"expressed in"| CLOCK
    AUTOPHAGY["AUTOPHAGY"]
    PER3 -->|"expressed in"| AUTOPHAGY
    APOPTOSIS["APOPTOSIS"]
    PER3 -->|"expressed in"| APOPTOSIS
    style PER3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Sleep Disorder	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
CRY1	associated_with	gene	0.60
NPAS2	associated_with	gene	0.60
CRY2	associated_with	gene	0.60
PER2	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	expressed_in	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
NPAS2	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
CANCER	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Autophagy	expressed_in	pathway	0.60
AND	expressed_in	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
CRY1	expressed_in	gene	0.60
CRY2	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
SIRT1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
PER1	associated_with	gene	0.60
PER1	expressed_in	gene	0.60
autism spectrum disorder	associated_with	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
MAPK signaling	participates_in	pathway	0.60
MTNR1B	associated_with	concept	0.50

Incoming (19)

Source	Relation	Type	Str
MTNR1B	associated_with	gene	0.60
PER1	associated_with	gene	0.60
PER2	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
MAPK	regulates	gene	0.60
NPAS2	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
HCRTR2	interacts_with	gene	0.60
PER2	interacts_with	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1B	expressed_in	gene	0.60
PER1	biomarker_for	gene	0.60
NR1D1	expressed_in	gene	0.60
ARNTL	associated_with	gene	0.50
CLOCK	associated_with	gene	0.50
NR1D1	associated_with	gene	0.50
HCRTR2	co_expressed_with	gene	0.50
PER2	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity