protein

TGFB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

9Outgoing

13Incoming

0Experiments

0Debates

Summary

TGFB3 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Migraine. Connected to 13 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TGFB3
Full Name	Transforming Growth Factor Beta 3
Chromosome	14q13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	TGF-β, TGF-β signaling
UniProt ID	P10615
NCBI Gene ID	7049
Ensembl ID	ENSG00000119699
OMIM	190230
GeneCards	TGFB3
Human Protein Atlas	TGFB3
Neuronal development	TGFB3 is critical for neural tube formation and neuronal differentiation during development[@stottmann2004]
Synaptogenesis	The cytokine regulates synapse formation and function[@fukuda2010]
Neuroprotection	TGFB3 protects neurons against various cytotoxic insults[@unsicker2013]
Wound healing	TGFB3 promotes tissue repair following neural injury[@eltzschig2018]
Associated Diseases	Migraine
KG Connections	22 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TGFB3 — AlphaFold P10615 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TGFB3 Gene

gene · 853 words

→

TGFB3 Protein

protein · 627 words

→

Pathway Diagram

graph TD
    TGFB3["TGFB3"]
    Migraine{"Migraine"}
    TGFB3 -->|"associated with"| Migraine
    neurodegeneration["neurodegeneration"]
    TGFB3 -->|"implicated in"| neurodegeneration
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| TGFB3
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| TGFB3
    TP53["TP53"]
    TP53 -->|"associated with"| TGFB3
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| TGFB3
    FXN["FXN"]
    FXN -->|"associated with"| TGFB3
    EPHA5["EPHA5"]
    EPHA5 -->|"associated with"| TGFB3
    EP300["EP300"]
    EP300 -->|"associated with"| TGFB3
    NLGN2["NLGN2"]
    NLGN2 -->|"associated with"| TGFB3
    CDK4["CDK4"]
    CDK4 -->|"associated with"| TGFB3
    CHD4["CHD4"]
    CHD4 -->|"associated with"| TGFB3
    HMGCR["HMGCR"]
    HMGCR -->|"associated with"| TGFB3
    style TGFB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Migraine	associated_with	disease	0.65
Epithelial	expressed_in	cell_type	0.60
Pdgf	expressed_in	protein	0.60
TGFB1	expressed_in	gene	0.60
TGFB2	expressed_in	gene	0.60
VEGFB	expressed_in	gene	0.60
CSF2	expressed_in	gene	0.60
Vegf	expressed_in	protein	0.60
Rb	expressed_in	protein	0.60

Incoming (13)

Source	Relation	Type	Str
VEGFA	expressed_in	gene	0.60
PDGFB	expressed_in	gene	0.60
KCNK5	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
NR1D1	associated_with	gene	0.60
FXN	associated_with	gene	0.60
EPHA5	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NLGN2	associated_with	gene	0.60
CDK4	associated_with	gene	0.60
CHD4	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TGFB3 in their description or question text

No additional research found