Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about REV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | REV |
| Protein Family | Nuclear receptor family, REV-ERB subfamily |
| Subcellular Localization | signal - **Ligand-binding domain (LBD)**: Binds heme as an endogenous ligand; co |
| Molecular Weight | ~51 kDa |
| Pathways | circadian regulation |
| UniProt ID | Q9UGL9 |
| GeneCards | REV |
| Human Protein Atlas | REV |
| Associated Diseases | ALS |
| Known Drugs/Compounds | lithium |
| Interactions | BMAL1, CLOCK, HDAC3 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
REV(["REV"])
style REV fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
circadian_regulation(["circadian regulation"])
HDAC3["HDAC3"]
BMAL1(["BMAL1"])
CLOCK["CLOCK"]
REV -->|"participates_in"| circadian_regulation
HDAC3 -->|"activates"| REV
BMAL1 -.->|"inhibits"| REV
CLOCK -.->|"inhibits"| REV
BMAL1 -->|"activates"| REV
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class circadian_regulation protein
class HDAC3 gene
class BMAL1 protein
class CLOCK gene| Target | Relation | Type | Str |
|---|---|---|---|
| circadian regulation | participates_in | pathway | 0.75 |
| neurons | expressed_in | cell_type | 0.70 |
| lipid metabolism | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| ALS | associated_with | disease | 0.60 |
| RNA | regulates | gene | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BMAL1 | regulates | gene | 0.70 |
| PER1 | regulates | gene | 0.70 |
| lithium | targets | drug | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| PER1 | associated_with | gene | 0.60 |
| ARNT | regulates | gene | 0.60 |
| ARNTL | regulates | gene | 0.60 |
| NR1D1 | regulates | gene | 0.60 |
| HDAC3 | activates | gene | 0.55 |
| BMAL1 | inhibits | gene | 0.55 |
| CLOCK | inhibits | gene | 0.55 |
| BMAL1 | activates | gene | 0.55 |
| NR1D1 | co_expressed_with | gene | 0.50 |
| PER1 | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State | in_vivo | neurodegeneration | 0.774 | 0.65 | C57BL/6J LPS model (chronic i. | proposed | $58,000 |
| Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat | in_vivo | post-cardiac-arrest neurodegen | 0.768 | 0.72 | Sprague-Dawley rat asphyxial c | abandoned | $48,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] | Albrechtsen HM, Saritas G, Winge SB, Mai | J Clin Endocrinol Metab | 2026 | 0 |
| Epigenetics in chronic rhinosinusitis. [PMID:41442742] | Kumar N, Brar T, Lal D | Curr Opin Otolaryngol Head Nec | 2026 | 0 |
| ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085] | Wen H, Zi Y, Liu Z, Bai Y, Lin J et al. | Cell Death Differ | 2026 | 0 |
| Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] | Jackson G, Islam H, de Souza Teixeira AA | Life Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Curr Alzheimer Res | 2026 | 0 |
| Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462] | Tan Y, Ye H, Ge Q, Wang P, Liu Z et al. | J Magn Reson Imaging | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] | Pavlović N, Todorović P, Maglica M, Kopi | Int J Mol Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Current Alzheimer research | 2026 | 0 |
| Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axon [PMID:41967652] | Fang J, Pan X, Chen J | Neurobiol Dis | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Al [PMID:40514243] | Jiang Y, Sachdeva K, Goulbourne CN, Berg | The Journal of neuroscience : | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| The cornel Iridoid glycoside attenuated brain edema of the cerebral ischemia/rep [PMID:38950636] | Wang Z, Xue F, Zhang J | Fitoterapia | 2024 | 0 |
| Chemical genetic activation of the cholinergic basal forebrain hippocampal circu [PMID:35418161] | Weilin Liu, Jianhong Li, Minguang Yang | {'name': "Alzheimer's Research | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning REV in their description or question text
Score: 0.843 · neurodegeneration · 2026-04-16
## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia
Score: 0.838 · neurodegeneration · 2026-04-17
## Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-A
Score: 0.837 · neurodegeneration · 2026-04-17
## Mechanistic Overview Microglial Senescence Prevention via TREM2/SASP Axis starts from the claim that modulating not y
Score: 0.812 · neurodegeneration · 2026-04-17
## Mechanistic Overview SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endo
Score: 0.803 · neurodegeneration · 2026-04-17
## Mechanistic Overview Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic
Score: 0.797 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f
Score: 0.789 · neurodegeneration · 2026-04-02
## Mechanistic Overview Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming starts from the claim
Score: 0.780 · neurodegeneration · 2026-04-25
Pharmacological NLRP3 inhibition via MCC950 breaks the lipid-inflammasome feedback loop that perpetuates microglial acti
Score: 0.766 · neurodegeneration · 2026-04-15
## Mechanistic Overview HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention starts from the claim th
Score: 0.740 · neurodegeneration · 2026-04-21
## Mechanistic Overview VPS35 retromer activation prevents endosomal tau templating across all brain regions and disease
Score: 0.735 · unknown disease · 2026-04-26
Nano-dose melatonin (0.1-0.3mg) produces optimal BACE1 suppression and antioxidant effects without disrupting endogenous
Score: 0.730 · neurodegeneration · 2026-04-21
## **Molecular Mechanism and Rationale** The pathological transition of stress granules from dynamic liquid-like conden
Score: 0.720 · neurodegeneration · 2026-04-26
Antisense oligonucleotides targeting C9orf72 hexanucleotide repeat expansion reduce toxic DPR proteins and RNA foci, res
Score: 0.720 · unknown disease · 2026-04-16
# Metabolic Reprogramming to Reverse Senescence in Neurodegeneration: A Mechanistic Hypothesis ## The Senescence Conund