gene

KCNK5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNK5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

17Outgoing

1Incoming

0Experiments

0Debates

Summary

Potassium two-pore domain channel gene KCNK5 (TASK-2)

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🧬 Gene Info

Gene Symbol	KCNK5
Aliases	TASK-2
Function	is a recognized contributor to progressive synaptic injury and circuit failure in AD/PD/ALS spectra.
Molecular Weight	51 kDa
NCBI Gene ID	3779
GeneCards	KCNK5
Human Protein Atlas	KCNK5
Associated Diseases	Migraine
KG Connections	18 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNK5 Gene

gene · 590 words

→

KCNK5 Protein

protein · 638 words

→

Pathway Diagram

graph TD
    KCNK5["KCNK5"]
    Fibrosis{"Fibrosis"}
    KCNK5 -->|"inhibits"| Fibrosis
    Als{"Als"}
    KCNK5 -->|"inhibits"| Als
    Migraine{"Migraine"}
    KCNK5 -->|"associated with"| Migraine
    KCNK6["KCNK6"]
    KCNK5 -->|"associated with"| KCNK6
    KCNK1["KCNK1"]
    KCNK5 -->|"associated with"| KCNK1
    KCNK2["KCNK2"]
    KCNK5 -->|"associated with"| KCNK2
    TGFB1["TGFB1"]
    KCNK5 -->|"associated with"| TGFB1
    TP53["TP53"]
    KCNK5 -->|"associated with"| TP53
    NR1D1["NR1D1"]
    KCNK5 -->|"associated with"| NR1D1
    FXN["FXN"]
    KCNK5 -->|"associated with"| FXN
    EPHA5["EPHA5"]
    KCNK5 -->|"associated with"| EPHA5
    EP300["EP300"]
    KCNK5 -->|"associated with"| EP300
    KCNK3["KCNK3"]
    KCNK3 -->|"associated with"| KCNK5
    style KCNK5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Migraine	associated_with	disease	0.65
TGFB1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
NR1D1	associated_with	gene	0.60
FXN	associated_with	gene	0.60
EPHA5	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NLGN2	associated_with	gene	0.60
CDK4	associated_with	gene	0.60
CHD4	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
TGFB3	associated_with	gene	0.60
KCNK6	associated_with	gene	0.60
KCNK1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
KCNK3	associated_with	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNK5 in their description or question text

No additional research found