protein

PER1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

PER1 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, associated with. Associated with Als, Alzheimer, Cancer. Connected to 59 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	Period Circadian Regulator 1
Chromosome	17p13.1
Function	PER1 (Period Circadian Regulator 1) is a core component of the mammalian circadian clock.
Molecular Weight	136 kDa
Pathways	Amyloid, Mtor, Pi3K/Akt, circadian regulation
UniProt ID	O15055
NCBI Gene ID	5441
Ensembl ID	ENSG00000132359
OMIM	602260
Associated Diseases	ALS, autism spectrum disorder
Known Drugs/Compounds	lithium
Interactions	AKT, AND, APP, BMAL1, CLOCK, CRY1
KG Connections	148 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PER1 — AlphaFold O15055 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PER1 Gene

gene · 604 words

→

PER1 Protein

protein · 689 words

→

Pathway Diagram

graph TD
    PER1["PER1"]
    Als{"Als"}
    PER1 -->|"therapeutic target"| Als
    Ms{"Ms"}
    PER1 -->|"interacts with"| Ms
    PER1 -->|"regulates"| Als
    PER1 -->|"regulates"| Ms
    PER1 -->|"expressed in"| Ms
    Carcinoma{"Carcinoma"}
    PER1 -->|"expressed in"| Carcinoma
    Cancer{"Cancer"}
    PER1 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    PER1 -->|"expressed in"| Tumor
    PER1 -->|"expressed in"| Als
    Schizophrenia{"Schizophrenia"}
    PER1 -->|"regulates"| Schizophrenia
    Circadian_Rhythm(["Circadian Rhythm"])
    PER1 -->|"therapeutic target"| Circadian_Rhythm
    GENES["GENES"]
    PER1 -->|"regulates"| GENES
    CRY1["CRY1"]
    CRY1 -->|"interacts with"| PER1
    BMAL1["BMAL1"]
    BMAL1 -->|"interacts with"| PER1
    CLOCK["CLOCK"]
    CLOCK -->|"interacts with"| PER1
    CLOCK -->|"associated with"| PER1
    BMAL1 -->|"associated with"| PER1
    PER3["PER3"]
    PER3 -->|"expressed in"| PER1
    PER3 -->|"associated with"| PER1
    style PER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (95)

Target	Relation	Type	Str
circadian regulation	participates_in	pathway	0.75
Circadian Rhythm	expressed_in	pathway	0.70
REV	regulates	gene	0.70
neurons	expressed_in	cell_type	0.70
apoptosis pathway	participates_in	pathway	0.70
CRY2	expressed_in	gene	0.70
CRY1	expressed_in	gene	0.70
CLOCK	expressed_in	gene	0.70
AKT	expressed_in	gene	0.70
PER2	expressed_in	gene	0.70
BMAL1	expressed_in	gene	0.70
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Sleep Disorder	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Autism	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Autism	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Schizophrenia	regulates	disease	0.65
GENES	regulates	gene	0.60
Mtor	activates	pathway	0.60
AND	inhibits	gene	0.60
AND	associated_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
REV	associated_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
RNA	regulates	gene	0.60
PI3K	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
FMR1	inhibits	gene	0.60
P38	inhibits	gene	0.60
TAU	inhibits	gene	0.60
Amyloid	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Rb	expressed_in	protein	0.60
PER3	associated_with	gene	0.60
AKT	activates	gene	0.60
PER3	biomarker_for	gene	0.60
Sleep-Wake	expressed_in	pathway	0.60

Incoming (53)

Source	Relation	Type	Str
CSNK1D	phosphorylates	gene	0.70
CRY1	activates	gene	0.65
CLOCK	activates	gene	0.65
BMAL1	activates	gene	0.65
BMAL1	associated_with	gene	0.60
PER3	associated_with	gene	0.60
PI3K	expressed_in	gene	0.60
CRY2	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
NPAS2	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
PER2	associated_with	gene	0.60
TAU	inhibits	gene	0.60
FMR1	inhibits	gene	0.60
NR1D1	regulates	gene	0.60
CLOCK	interacts_with	gene	0.60
CLOCK	associated_with	gene	0.60
lithium	targets	drug	0.60
ARNT	regulates	gene	0.60
ARNTL	regulates	gene	0.60
CRY1	interacts_with	gene	0.60
PER3	expressed_in	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	interacts_with	gene	0.60
CRY2	interacts_with	gene	0.60
BMAL1	interacts_with	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1B	associated_with	gene	0.60
APP	activates	gene	0.60
PI3K	activates	gene	0.60
MAPK	inhibits	gene	0.60
MTOR	activates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
APP/PS1	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CLOCK GENE	expressed_in	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
CRY2	activates	gene	0.55
HDAC3	activates	gene	0.55
CRY1	expressed_in	gene	0.55
CLOCK	regulates	gene	0.55
BMAL1	regulates	gene	0.55
FMR1	activates	gene	0.50
MTNR1A	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning PER1 in their description or question text

No additional research found