gene

NPAS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPAS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

24Outgoing

15Incoming

0Experiments

0Debates

Summary

Neuronal PAS Domain Protein 2 - circadian clock transcription factor

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🧬 Gene Info

Gene Symbol	NPAS2
Full Name	Neuronal PAS Domain Protein 2
Chromosome	2q22.1
Function	The NPAS2 gene encodes Neuronal PAS Domain Protein 2, a transcription factor that serves as a core component of the mammalian circadian clock.
Molecular Weight	87 kDa
Pathways	CBFs
UniProt ID	Q8BZD0
NCBI Gene ID	10327
Ensembl ID	ENSG00000107077
OMIM	605504
GeneCards	NPAS2
Human Protein Atlas	NPAS2
Associated Diseases	Freezing Tolerance
Interactions	BMAL1, MTNR1A, MTNR1B, PER1, PER2
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NPAS2 — AlphaFold Q8BZD0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NPAS2 Gene

gene · 727 words

→

NPAS2 Protein

protein · 635 words

→

Pathway Diagram

graph TD
    NPAS2["NPAS2"]
    BMAL1["BMAL1"]
    NPAS2 -->|"interacts with"| BMAL1
    CRY2["CRY2"]
    NPAS2 -->|"associated with"| CRY2
    PER2["PER2"]
    NPAS2 -->|"associated with"| PER2
    CLOCK["CLOCK"]
    NPAS2 -->|"associated with"| CLOCK
    NPAS2 -->|"associated with"| BMAL1
    neurodegeneration["neurodegeneration"]
    NPAS2 -->|"implicated in"| neurodegeneration
    PER3["PER3"]
    PER3 -->|"associated with"| NPAS2
    PER1["PER1"]
    PER1 -->|"associated with"| NPAS2
    CRY1["CRY1"]
    CRY1 -->|"associated with"| NPAS2
    style NPAS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
HOS1	interacts_with	enzyme	0.80
CBFs	participates_in	pathway	0.80
Freezing Tolerance	associated_with	phenotype	0.80
BMAL1	interacts_with	protein	0.70
Autism	expressed_in	disease	0.65
Sleep Disorder	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
MTNR1A	associated_with	gene	0.60
PER3	expressed_in	gene	0.60
PER1	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	associated_with	gene	0.60
CLOCK	expressed_in	gene	0.60
ARNTL	expressed_in	gene	0.60
CRY2	associated_with	gene	0.60
PER2	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
autism spectrum disorder	interacts_with	disease	0.60
Rb	expressed_in	protein	0.60
PER1	interacts_with	protein	0.50
PER2	interacts_with	protein	0.50
MTNR1B	interacts_with	concept	0.50

Incoming (15)

Source	Relation	Type	Str
genes-npas2	linked_to	wiki_page	1.00
PER1	associated_with	gene	0.60
CRY1	associated_with	gene	0.60
ARNTL	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
PER3	associated_with	gene	0.60
MTNR1B	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
PER2	associated_with	gene	0.60
MTNR1B	interacts_with	gene	0.60
MTNR1A	associated_with	gene	0.60
CLOCK	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AND	associated_with	gene	0.60
MTNR1A	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPAS2 in their description or question text

No additional research found