protein

PER2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PER2 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Als, Alzheimer, Autism. Connected to 106 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	Period Circadian Regulator 2
Chromosome	2p13
Function	PER2 is a core clock gene essential for circadian rhythm generation.
Molecular Weight	180 kDa
Pathways	Akt, Circadian Rhythm, Lipid Metabolism, Mtor, Pi3K
UniProt ID	Q8BZD0
NCBI Gene ID	8864
Ensembl ID	ENSG00000132266
OMIM	603714
Associated Diseases	ALS, autism spectrum disorder, Ms
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections	200 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PER2 — AlphaFold Q8BZD0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PER2 Gene

gene · 744 words

→

PER2 Protein

protein · 627 words

→

Pathway Diagram

graph TD
    PER2["PER2"]
    PER2 -->|"regulates"| Als["Als"]
    PER2 -->|"activates"| Ms["Ms"]
    PER2 -->|"regulates"| Autism["Autism"]
    PER2 -->|"expressed in"| Carcinoma["Carcinoma"]
    PER2 -->|"expressed in"| Cancer["Cancer"]
    PER2 -->|"expressed in"| Tumor["Tumor"]
    CRY1["CRY1"] -->|"interacts"| PER2
    BMAL1["BMAL1"] -->|"interacts"| PER2
    CLOCK["CLOCK"] -->|"interacts"| PER2
    GENES["GENES"] -->|"regulates"| PER2
    PER1["PER1"] -->|"expressed in"| PER2
    AKT["AKT"] -->|"expressed in"| PER2
    MTOR["MTOR"] -->|"regulates"| PER2
    FASN["FASN"] -->|"regulates"| PER2

Outgoing (111)

Target	Relation	Type	Str
PD-L1	inhibits	protein	0.95
NF-κB	inhibits	pathway	0.95
HSP90	binds_to	protein	0.92
oral squamous cell carcinoma	protects_against	disease	0.88
IKK	promotes	protein	0.88
Circadian Rhythm	expressed_in	pathway	0.80
circadian regulation	participates_in	pathway	0.75
Sleep Disorder	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Diabetes	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Ms	associated_with	disease	0.65
Ataxia	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Autism	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
AKT	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
PER1	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	associated_with	gene	0.60
ARNTL	expressed_in	gene	0.60
Akt	activates	pathway	0.60
AMYLOID	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
Mtor	expressed_in	pathway	0.60
Pi3K/Akt	expressed_in	pathway	0.60
autism spectrum disorder	interacts_with	disease	0.60
autism spectrum disorder	associated_with	disease	0.60
APP	expressed_in	gene	0.60
Mtor	activates	pathway	0.60

Incoming (89)

Source	Relation	Type	Str
h-de52344d	targets_gene	hypothesis	0.90
PER1	expressed_in	gene	0.70
CRY1	expressed_in	gene	0.70
CRY2	expressed_in	gene	0.70
CRY1	activates	gene	0.65
CLOCK	interacts_with	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	regulates	gene	0.60
PER3	expressed_in	gene	0.60
MTNR1A	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
BMAL1	interacts_with	gene	0.60
MTNR1B	interacts_with	gene	0.60
MTOR	activates	gene	0.60
APP	activates	gene	0.60
PI3K	activates	gene	0.60
CRY2	interacts_with	gene	0.60
APP/PS1	expressed_in	gene	0.60
CRY1	interacts_with	gene	0.60
CRY2	regulates	gene	0.60
MTOR	regulates	gene	0.60
FASN	regulates	gene	0.60
CRY1	regulates	gene	0.60
AKT	regulates	gene	0.60
NAMPT	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
UBR5	inhibits	gene	0.60
FASN	expressed_in	gene	0.60
NFKBIA	expressed_in	gene	0.60
PGC1A	expressed_in	gene	0.60
PER3	associated_with	gene	0.60
PER1	associated_with	gene	0.60
CRY1	associated_with	gene	0.60
NPAS2	associated_with	gene	0.60
CRY2	associated_with	gene	0.60
AKT	activates	gene	0.60
SLC31A1	activates	gene	0.60
BMAL1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
PER1	regulates	gene	0.60
GENES	regulates	gene	0.60
CLOCK	activates	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1B	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PER2 in their description or question text

No additional research found