Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ADAMTS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ADAMTS1 |
| Key Genes/Proteins | CAV1, ESM1, HPSE, ICAM1, MMP2, MMP9 |
| Related Diseases | podocyte foot process effacement, proteinuria |
Knowledge base pages for this entity
graph TD
ADAMTS1[ADAMTS1]
ADAMTS1 -->|activates| CAV1[CAV1]
ADAMTS1 -->|activates| ESM1[ESM1]
ADAMTS1 -->|activates| HPSE[HPSE]
ADAMTS1 -->|activates| ICAM1[ICAM1]
ADAMTS1 -->|activates| MMP2[MMP2]
ADAMTS1 -->|activates| MMP9[MMP9]
ADAMTS1 -->|activates| NOS3[NOS3]
benchmark_ot_ad_answer_key_ADA[benchmark_ot_ad_answer_key:ADAMTS1] -->|data_in| ADAMTS1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ADAMTS1 | data_in | dataset_row | 0.00 |
| proteinuria | associated_with | phenotype | 0.80 |
| podocyte foot process effacement | associated_with | phenotype | 0.80 |
| CAV1 | activates | gene | 0.60 |
| ESM1 | activates | gene | 0.60 |
| HPSE | activates | gene | 0.60 |
| ICAM1 | activates | gene | 0.60 |
| MMP2 | activates | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| NOS3 | activates | gene | 0.60 |
| CAV1 | interacts_with | gene | 0.60 |
| HPSE | interacts_with | gene | 0.60 |
| ICAM1 | interacts_with | gene | 0.60 |
| NOS3 | interacts_with | gene | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ADAMTS1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ADAMTS1 in their description or question text
No additional research found