gene 603 words KG: NOS3
Contents

NOS3 — Nitric Oxide Synthase 3

🧬 Gene Info
Gene SymbolNOS3
Full NameNitric Oxide Synthase 3
Chromosome7q36
Protein TypeProtein
FunctionThis is the basis for the therapeutic use of nitrates in cardiovascular disease [@katusic2009].
Primary Expressionvascular endothelial cells where it catalyzes the production of nitric oxide (NO) from L-arginine
Amino Acids490 aa
PathwaysMapk, autophagy pathway, complement cascade, phagocytosis
UniProt IDSearch UniProt
GeneCardsNOS3
Human Protein AtlasNOS3
Associated DiseasesALS, Alzheimer, Cancer, podocyte foot process effacement
Known Drugs/Compoundsrapamycin
InteractionsACOX1, ADAMTS1, Adiponectin, ADIPOQ, AMPK, AND
KG Connections382 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
APOE-Dependent Autophagy Restoration
Score: 0.85
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74

Related Analyses (6)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
AKT1 Gene
gene · KG edge: therapeutic_target
ARG1 — Arginase 1
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PPARA interacts_with NOS3
ULK1 interacts_with NOS3
STX17 interacts_with NOS3
SQSTM1 interacts_with NOS3
NOS3 interacts_with STING1
NOS3 interacts_with GLP1R
NOS3 interacts_with SREBF1
NOS3 interacts_with SIRT1
NOS3 interacts_with KDM6B
NOS3 interacts_with LC3

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