gene

NCAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NCAM1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, expressed in. Associated with ALS, Als, Bipolar. Connected to 93 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NCAM1
Function	NCAM1 encodes a cell adhesion molecule essential for neural development and plasticity.
Molecular Weight	220 kDa
Pathways	MAPK, PI3K
Ensembl ID	ENSG00000149294
GeneCards	NCAM1
Human Protein Atlas	NCAM1
Cell adhesion	Mediates homophilic (NCAM-NCAM) and heterophilic interactions with other cell surface proteins
Neuronal migration	Guides neuronal precursors during brain development
Axon guidance	Provides directional cues for growing axons
Synaptogenesis	Promotes formation and maintenance of synapses
Signal transduction	Activates intracellular signaling through FGFR, p59fyn, and other kinases
Associated Diseases	Als, Bipolar, Depression, Ms, Schizophrenia
Interactions	APOPTOSIS, CANCER, CDKN2A, COL4A1, DAO, DCC
KG Connections	135 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NCAM1 Gene

gene · 822 words

→

NCAM1 Protein

protein · 903 words

→

Pathway Diagram

graph TD
    NCAM1["NCAM1"]
    NCAM1 -->|"inhibits"| Carcinoma["Carcinoma"]
    NCAM1 -->|"inhibits"| Ms["Ms"]
    NCAM1 -->|"inhibits"| Cancer["Cancer"]
    NCAM1 -->|"inhibits"| Tumor["Tumor"]
    NCAM1 -->|"expressed in"| DNMT1["DNMT1"]
    NCAM1 -->|"expressed in"| AKT1["AKT1"]
    NCAM1 -->|"expressed in"| COMT["COMT"]
    NCAM1 -->|"expressed in"| DLGAP2["DLGAP2"]
    NCAM1 -->|"expressed in"| STAT3["STAT3"]
    NCAM1 -->|"expressed in"| ARG1["ARG1"]
    PENK["PENK"] -->|"expressed in"| NCAM1
    CDKN2A["CDKN2A"] -->|"inhibits"| NCAM1
    TLR4["TLR4"] -->|"inhibits"| NCAM1
    CANCER["CANCER"] -->|"inhibits"| NCAM1
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| NCAM1
    TNC["TNC"] -->|"inhibits"| NCAM1
    NTRK2["NTRK2"] -->|"inhibits"| NCAM1
    PAK1["PAK1"] -->|"inhibits"| NCAM1
    WNT7A["WNT7A"] -->|"inhibits"| NCAM1
    LZTS1["LZTS1"] -->|"inhibits"| NCAM1

Outgoing (78)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	associated_with	disease	0.65
GABRA5	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
Circadian Rhythm	associated_with	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Bdnf	associated_with	protein	0.60
RGS4	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
HTTLPR	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
G72	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
App	associated_with	protein	0.60
RGS1	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
DEPRESSION	associated_with	gene	0.60
COL4A1	inhibits	gene	0.60
Epigenetic	associated_with	pathway	0.60
Akt	expressed_in	pathway	0.60
FOXP2	regulates	gene	0.60
CACNA1E	regulates	gene	0.60
DCC	regulates	gene	0.60
TRAF3	regulates	gene	0.60
Rb	associated_with	protein	0.60
RGS4	interacts_with	gene	0.60

Incoming (57)

Source	Relation	Type	Str
G72	interacts_with	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	associated_with	gene	0.60
FGF10	inhibits	gene	0.60
DLC1	inhibits	gene	0.60
KCNH1	inhibits	gene	0.60
HTTLPR	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
G72	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
DNA	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DAO	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
PENK	expressed_in	gene	0.60
GRM8	regulates	gene	0.60
GRIA1	regulates	gene	0.60
DEPRESSION	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
CACNA1E	regulates	gene	0.60
DCC	regulates	gene	0.60
ESR1	regulates	gene	0.60
FOXP2	regulates	gene	0.60
AND	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
DAO	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NCAM1 in their description or question text

No additional research found