| Gene Symbol | NCAM1 |
| Aliases | NCAM1PROTEIN |
| Function | NCAM1 encodes a cell adhesion molecule essential for neural development and plasticity. |
| Subcellular Localization | </th><td>Cell membrane (Type I membrane protein)</td></tr> |
| Molecular Weight | 220 kDa |
| Pathways | MAPK, PI3K |
| Ensembl ID | ENSG00000149294 |
| GeneCards | NCAM1 |
| Human Protein Atlas | NCAM1 |
| N-terminal Signal Peptide | Targets protein for secretion/membrane insertion |
| Five Ig-like Domains | Immunoglobulin-like domains (IgI-V) mediating homophilic binding |
| Transmembrane Domain | Single-pass membrane-spanning region |
| Cytoplasmic Tail | Intracellular domain interacting with cytoskeletal proteins |
| NCAM-120 | GPI-anchored form (120 kDa) |
| NCAM-140 | Transmembrane form (140 kDa) |
| Associated Diseases | Als, Bipolar, Depression, Ms, Schizophrenia |
| Interactions | APOPTOSIS, CANCER, CDKN2A, COL4A1, DAO, DCC |
| KG Connections | 135 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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