gene

RGS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

19Outgoing

32Incoming

0Experiments

0Debates

Summary

Page for RGS1 — Regulator of G Protein Signaling 1

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🧬 Gene Info

Gene Symbol	RGS1
Full Name	Regulator of G Protein Signaling 1
Chromosome	1q31.2
Function	This activity rapidly terminates GPCR signaling by promoting Gα-GTP reassociation with Gβγ dimers, effectively serving as a molecular timer for GPCR signal transduction.
Primary Expression	Lymphoid tissues, Spleen, Lymph nodes, Blood leukocytes
Amino Acids	206 aa
UniProt ID	Q08169
NCBI Gene ID	5996
Ensembl ID	ENSG00000190125
OMIM	607070
GeneCards	RGS1
Human Protein Atlas	RGS1
Interactions	ANXA2, APOPTOSIS, ASTROCYTES, ATF3, CANCER, CD14
KG Connections	51 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RGS1 — AlphaFold Q08169 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RGS1["RGS1"]
    Inflammation{"Inflammation"}
    RGS1 -->|"activates"| Inflammation
    Stroke{"Stroke"}
    RGS1 -->|"activates"| Stroke
    Als{"Als"}
    RGS1 -->|"activates"| Als
    Ischemia{"Ischemia"}
    RGS1 -->|"activates"| Ischemia
    Ms{"Ms"}
    RGS1 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    RGS1 -->|"inhibits"| Carcinoma
    RGS1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    RGS1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    RGS1 -->|"inhibits"| Tumor
    ZFP36["ZFP36"]
    RGS1 -->|"activates"| ZFP36
    HSPB1["HSPB1"]
    RGS1 -->|"activates"| HSPB1
    CH25H["CH25H"]
    RGS1 -->|"activates"| CH25H
    ANXA2["ANXA2"]
    ANXA2 -->|"activates"| RGS1
    ICAM1["ICAM1"]
    ICAM1 -->|"activates"| RGS1
    CD44["CD44"]
    CD44 -->|"activates"| RGS1
    HMOX1["HMOX1"]
    HMOX1 -->|"activates"| RGS1
    SPP1["SPP1"]
    SPP1 -->|"activates"| RGS1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| RGS1
    TIMP1["TIMP1"]
    TIMP1 -->|"activates"| RGS1
    LGALS3["LGALS3"]
    LGALS3 -->|"activates"| RGS1
    CD14["CD14"]
    CD14 -->|"activates"| RGS1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| RGS1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| RGS1
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| RGS1
    style RGS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
RAB27A	inhibits	gene	0.60
COL4A1	inhibits	gene	0.60
ZFP36	activates	gene	0.60
HSPB1	activates	gene	0.60
CH25H	activates	gene	0.60
ATF3	activates	gene	0.60
Mapk	inhibits	pathway	0.60
VIM	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
genes-rgs1	describes	wiki_page	1.00
genes-rgs1	documents	wiki_page	1.00
ICAM1	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
CD14	activates	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
DLC1	inhibits	gene	0.60
KCNH1	associated_with	gene	0.60
NCAM1	inhibits	gene	0.60
ANXA2	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CD33	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PILRB	interacts_with	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RGS1 in their description or question text

No additional research found

RGS1

Understanding Entity Pages

Summary

Wiki Pages (6)

RGS1 — Regulator of G Protein Signaling 1

RGS10 Gene

RGS12 Protein

RGS12 Gene

RGS14 Protein

RGS11 — Regulator of G Protein Signaling 11