gene

DAO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

0Experiments

0Debates

Summary

D-Amino Acid Oxidase - enzyme critical for D-serine metabolism and NMDA receptor signaling, implicated in ALS, schizophrenia, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DAO
Full Name	D-Amino Acid Oxidase
Chromosome	12q24.11
Protein Type	Enzyme
Function	encodes a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidative deamination of D-amino acids.
Primary Expression	Brain (neurons, astrocytes), liver, kidney
Molecular Weight	39 kDa
Amino Acids	347 aa
UniProt ID	P14920
NCBI Gene ID	1680
Ensembl ID	ENSG00000110888
OMIM	124050
GeneCards	DAO
Human Protein Atlas	DAO
Associated Diseases	Als, Bipolar, Depression, Ms, Schizophrenia
Interactions	DISC1, G72, GRIN2B, GRM3, GRM4, NCAM1
KG Connections	91 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DAO — AlphaFold P14920 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

DAOIBplusAO Phase 2 (NCT06467539) - Novel Antioxidant Augmentation for Early Dementia

clinical · 788 words

→

VitaDAO (Longevity Research DAO)

ai_tool · 457 words

→

Pathway Diagram

graph TD
    DAO["DAO"]
    Schizophrenia{"Schizophrenia"}
    DAO -->|"associated with"| Schizophrenia
    Als{"Als"}
    DAO -->|"associated with"| Als
    Depression{"Depression"}
    DAO -->|"associated with"| Depression
    Bipolar{"Bipolar"}
    DAO -->|"associated with"| Bipolar
    Ms{"Ms"}
    DAO -->|"associated with"| Ms
    ALS{"ALS"}
    DAO -->|"associated with"| ALS
    BMAL1["BMAL1"]
    DAO -->|"associated with"| BMAL1
    GRM4["GRM4"]
    DAO -->|"associated with"| GRM4
    SYNGR1["SYNGR1"]
    DAO -->|"associated with"| SYNGR1
    BDNF["BDNF"]
    DAO -->|"associated with"| BDNF
    NCAM1["NCAM1"]
    DAO -->|"associated with"| NCAM1
    RGS4["RGS4"]
    DAO -->|"associated with"| RGS4
    HTR2A["HTR2A"]
    HTR2A -->|"associated with"| DAO
    DISC1["DISC1"]
    DISC1 -->|"associated with"| DAO
    FKBP5["FKBP5"]
    FKBP5 -->|"associated with"| DAO
    NRG1["NRG1"]
    NRG1 -->|"associated with"| DAO
    HTTLPR["HTTLPR"]
    HTTLPR -->|"associated with"| DAO
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"associated with"| DAO
    BDNF -->|"associated with"| DAO
    PERIOD3["PERIOD3"]
    PERIOD3 -->|"associated with"| DAO
    GRM4 -->|"associated with"| DAO
    G72["G72"]
    G72 -->|"associated with"| DAO
    TRPM2["TRPM2"]
    TRPM2 -->|"associated with"| DAO
    GENES["GENES"]
    GENES -->|"associated with"| DAO
    style DAO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
NCAM1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
Circadian Rhythm	associated_with	pathway	0.60
BMAL1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
G72	interacts_with	gene	0.60
AND	associated_with	gene	0.60
Bdnf	associated_with	protein	0.60
DCTN1	associated_with	gene	0.60
FIG4	associated_with	gene	0.60
FUS	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
SCHIZOPHRENIA	associated_with	entity	0.60
SETX	associated_with	gene	0.60
SPG11	associated_with	gene	0.60
TAF15	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
VAPB	associated_with	gene	0.60
VCP	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
GRIN2B	interacts_with	gene	0.60
GRM3	interacts_with	gene	0.60
GRM4	interacts_with	gene	0.60
NCAM1	interacts_with	gene	0.60
NRG1	interacts_with	gene	0.60
RGS4	interacts_with	gene	0.60
SYNGR1	interacts_with	gene	0.60
schizophrenia	interacts_with	disease	0.60
DISC1	interacts_with	gene	0.60
PDLIM5	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60

Incoming (30)

Source	Relation	Type	Str
ALS	associated_with	gene	0.60
ALS2	associated_with	gene	0.60
ANG	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DNA	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
POLG	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
HTTLPR	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
G72	associated_with	gene	0.60
GENES	associated_with	gene	0.60
BDNF	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DAO in their description or question text

No additional research found

DAO