gene

TNC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

50Outgoing

16Incoming

0Experiments

0Debates

Summary

TNC is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TNC
Full Name	Tenascin C
Chromosome	9
Function	The TNC gene encodes Tenascin C, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum.
Primary Expression	various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum
Pathways	Inflammasome, Nf-Κb
UniProt ID	P24821
Ensembl ID	ENSG00000052850
OMIM	187380
GeneCards	TNC
Human Protein Atlas	TNC
Associated Diseases	Als, Entheseal new bone formation, Extracellular matrix adhesion force, Fibrosis, Liver fibrosis
Known Drugs/Compounds	metformin
Interactions	AMPK, APOPTOSIS, ARG1, CANCER, CD44, CDKN2A
KG Connections	74 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TNC — AlphaFold P24821 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNC Gene

gene · 736 words

→

Tenascin-C Protein (Tenascin-C, TNC)

protein · 548 words

→

Pathway Diagram

graph TD
    TNC["TNC"]
    Carcinoma{"Carcinoma"}
    TNC -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    TNC -->|"inhibits"| Ms
    Cancer{"Cancer"}
    TNC -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    TNC -->|"inhibits"| Tumor
    NTRK2["NTRK2"]
    TNC -->|"associated with"| NTRK2
    PAK1["PAK1"]
    TNC -->|"inhibits"| PAK1
    WNT7A["WNT7A"]
    TNC -->|"inhibits"| WNT7A
    LZTS1["LZTS1"]
    TNC -->|"inhibits"| LZTS1
    DCC["DCC"]
    TNC -->|"inhibits"| DCC
    KCNK2["KCNK2"]
    TNC -->|"inhibits"| KCNK2
    CD44["CD44"]
    TNC -->|"inhibits"| CD44
    FGF10["FGF10"]
    TNC -->|"inhibits"| FGF10
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| TNC
    TLR4["TLR4"]
    TLR4 -->|"associated with"| TNC
    CANCER["CANCER"]
    CANCER -->|"inhibits"| TNC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| TNC
    style TNC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (58)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TNC	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Extracellular matrix adhesion force	associated_with	phenotype	0.80
Entheseal new bone formation	associated_with	phenotype	0.80
Macrophage activation	associated_with	cell_type	0.80
Liver fibrosis	associated_with	disease	0.80
Tumor	inhibits	disease	0.65
Migraine	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
C-FOS	activates	gene	0.60
KCNH1	inhibits	gene	0.60
NCAM1	inhibits	gene	0.60
RGS1	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
COL4A1	inhibits	gene	0.60
SYK	regulates	gene	0.60
NLRP3	activates	gene	0.60
TREM2	activates	gene	0.60
ARG1	activates	gene	0.60
UHRF1	activates	gene	0.60
FOS	activates	gene	0.60
TREM2	regulates	gene	0.60
neuroinflammation	regulates	disease	0.60
TREM2	expressed_in	gene	0.60
TREM1	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
DLC1	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Microglia	activates	cell_type	0.60
IL-1	inhibits	gene	0.60
IL-4	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
MICROGLIA	associated_with	gene	0.60

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TNC	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
PPARG	regulates	gene	0.70
MICROGLIA	activates	gene	0.60
AMPK	activates	gene	0.60
TLR4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
CDKN2A	inhibits	gene	0.60
C-FOS	activates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
metformin	targets	drug	0.60
NLRP3	activates	gene	0.60
SYK	regulates	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNC in their description or question text

No additional research found