gene

DLC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

12Outgoing

13Incoming

0Experiments

0Debates

Summary

DLC1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, implicated in. Associated with Cancer, Carcinoma, Ms. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DLC1
Aliases	Page for DLC1 Gene
Chromosome	8p22.
Function	DLC1 (Deleted in Liver Cancer 1) is a GTPase-activating protein (GAP) that specifically inactivates Rho family GTPases, primarily RhoA, Rac1, and Cdc42.
Primary Expression	dopaminergic neurons where it may protect against oxidative stress
Pathways	Apoptosis, Wnt, Mapk
Ensembl ID	ENSG00000121667
GeneCards	DLC1
Human Protein Atlas	DLC1
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, CANCER, CD44, FGF10, KCNH1, KCNK2
KG Connections	25 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DLC1 Gene - Deleted in Liver Cancer 1

gene · 649 words

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Pathway Diagram

graph TD
    DLC1["DLC1"]
    Carcinoma{"Carcinoma"}
    DLC1 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    DLC1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    DLC1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    DLC1 -->|"inhibits"| Tumor
    KCNH1["KCNH1"]
    DLC1 -->|"inhibits"| KCNH1
    NCAM1["NCAM1"]
    DLC1 -->|"inhibits"| NCAM1
    RGS1["RGS1"]
    DLC1 -->|"inhibits"| RGS1
    RAB27A["RAB27A"]
    DLC1 -->|"inhibits"| RAB27A
    COL4A1["COL4A1"]
    DLC1 -->|"associated with"| COL4A1
    Apoptosis(["Apoptosis"])
    DLC1 -->|"inhibits"| Apoptosis
    Wnt(["Wnt"])
    DLC1 -->|"associated with"| Wnt
    Mapk(["Mapk"])
    DLC1 -->|"inhibits"| Mapk
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| DLC1
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| DLC1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| DLC1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| DLC1
    TNC["TNC"]
    TNC -->|"inhibits"| DLC1
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| DLC1
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| DLC1
    WNT7A["WNT7A"]
    WNT7A -->|"associated with"| DLC1
    LZTS1["LZTS1"]
    LZTS1 -->|"associated with"| DLC1
    DCC["DCC"]
    DCC -->|"associated with"| DLC1
    KCNK2["KCNK2"]
    KCNK2 -->|"inhibits"| DLC1
    CD44["CD44"]
    CD44 -->|"inhibits"| DLC1
    style DLC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Apoptosis	inhibits	pathway	0.60
Wnt	associated_with	pathway	0.60
Mapk	inhibits	pathway	0.60
KCNH1	inhibits	gene	0.60
NCAM1	inhibits	gene	0.60
RGS1	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
COL4A1	associated_with	gene	0.60

Incoming (13)

Source	Relation	Type	Str
CDKN2A	associated_with	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	associated_with	gene	0.60
LZTS1	associated_with	gene	0.60
DCC	associated_with	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLC1 in their description or question text

No additional research found