gene

KCNH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

11Outgoing

14Incoming

0Experiments

0Debates

Summary

KCNH1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in, associated with. Associated with Cancer, Carcinoma, Ms. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KCNH1
Full Name	Potassium Voltage-Gated Channel Subfamily H Member 1
Chromosome	1p36.33
Protein Type	Channel
Function	is a voltage-gated potassium channel with unique properties in neuronal excitability, cell proliferation, and synaptic transmission.
Amino Acids	958 aa
UniProt ID	Q14721
NCBI Gene ID	3756
Ensembl ID	ENSG00000128408
OMIM	603305
GeneCards	KCNH1
Human Protein Atlas	KCNH1
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, CANCER, CD44, CDKN2A, COL4A1, DCC
KG Connections	25 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNH1 — AlphaFold Q14721 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNH1 Gene

gene · 862 words

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Pathway Diagram

graph TD
    KCNH1["KCNH1"]
    Carcinoma{"Carcinoma"}
    KCNH1 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    KCNH1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    KCNH1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    KCNH1 -->|"inhibits"| Tumor
    NCAM1["NCAM1"]
    KCNH1 -->|"inhibits"| NCAM1
    RGS1["RGS1"]
    KCNH1 -->|"associated with"| RGS1
    RAB27A["RAB27A"]
    KCNH1 -->|"inhibits"| RAB27A
    COL4A1["COL4A1"]
    KCNH1 -->|"inhibits"| COL4A1
    Apoptosis(["Apoptosis"])
    KCNH1 -->|"inhibits"| Apoptosis
    Wnt(["Wnt"])
    KCNH1 -->|"inhibits"| Wnt
    Mapk(["Mapk"])
    KCNH1 -->|"inhibits"| Mapk
    neurodegeneration["neurodegeneration"]
    KCNH1 -->|"implicated in"| neurodegeneration
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| KCNH1
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| KCNH1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| KCNH1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| KCNH1
    TNC["TNC"]
    TNC -->|"inhibits"| KCNH1
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| KCNH1
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| KCNH1
    WNT7A["WNT7A"]
    WNT7A -->|"inhibits"| KCNH1
    LZTS1["LZTS1"]
    LZTS1 -->|"inhibits"| KCNH1
    DCC["DCC"]
    DCC -->|"inhibits"| KCNH1
    KCNK2["KCNK2"]
    KCNK2 -->|"inhibits"| KCNH1
    CD44["CD44"]
    CD44 -->|"inhibits"| KCNH1
    style KCNH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Apoptosis	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
NCAM1	inhibits	gene	0.60
Mapk	inhibits	pathway	0.60
RGS1	associated_with	gene	0.60
RAB27A	inhibits	gene	0.60
COL4A1	inhibits	gene	0.60

Incoming (14)

Source	Relation	Type	Str
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
DLC1	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNH1 in their description or question text

No additional research found