gene

ARG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

229Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARG1
Full Name	Arginase 1
Aliases	Arginase-1, Liver arginase
Chromosome	6q23.2
Function	Urea cycle enzyme, hydrolyzes arginine to ornithine
Primary Expression	the brain, where it plays important roles in modulating nitric oxide (NO) production, polyamine synthesis, and immune cell function[^2]
Molecular Weight	34.7 kDa
Amino Acids	330
Pathways	Urea cycle, Arginine metabolism
UniProt ID	P05089
NCBI Gene ID	383
Ensembl ID	ENSG00000118520
OMIM	608313
GeneCards	ARG1
Human Protein Atlas	ARG1
Associated Diseases	Aging, Alzheimer, Cancer, Dementia, Ms, Tumor
Interactions	ABCA1, ABCG1, AHR, AKT, AMPK, AND
KG Connections	226 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ARG1 — AlphaFold P05089 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ARG1 — Arginase 1

gene · 1643 words

→

ARG1 Protein

protein · 1300 words

→

Pathway Diagram

graph TD
    ARG1["ARG1"] -.->|"inhibits"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -->|"interacts"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -.->|"inhibits"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -->|"activates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    PENK["PENK"] -->|"expressed in"| ARG1["ARG1"]
    style PENK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NCAM1["NCAM1"] -->|"expressed in"| ARG1["ARG1"]
    style NCAM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DNMT1["DNMT1"] -->|"expressed in"| ARG1["ARG1"]
    style DNMT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT1["AKT1"] -->|"expressed in"| ARG1["ARG1"]
    style AKT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMT["COMT"] -->|"expressed in"| ARG1["ARG1"]
    style COMT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ARG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (188)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARG1	data_in	dataset_row	0.00
tissue repair	involved_in	process	0.90
MICROGLIA	expressed_in	cell_type	0.90
efferocytosis	regulates	process	0.85
scar formation	involved_in	process	0.85
efferocytosis	involved_in	process	0.85
Inflammation	inhibits	disease	0.75
Inflammation	activates	disease	0.75
unfolded protein response	participates_in	pathway	0.75
INFLAMMATION	activates	gene	0.70
M2 anti-inflammatory phenotype	biomarker_for	cell_type	0.70
Cancer	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Inflammation	biomarker_for	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Depression	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	interacts_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
TGF	activates	gene	0.65
TGF-beta signaling	participates_in	pathway	0.65
Stroke	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
CYTOKINES	biomarker_for	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Microglia	biomarker_for	cell_type	0.60
ABCG1	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
ATG5	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
P62	inhibits	gene	0.60
CD36	inhibits	gene	0.60
LC3	inhibits	gene	0.60
AKT	inhibits	gene	0.60
HMGB1	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60

Incoming (41)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARG1	data_in	dataset_row	0.00
Irisin	upregulates	protein	0.90
INFLAMMATION	activates	gene	0.60
RNA	associated_with	gene	0.60
AMPK	activates	gene	0.60
IL-1	activates	gene	0.60
IL-4	activates	gene	0.60
DEPRESSION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
STAT3	activates	gene	0.60
NCAM1	expressed_in	gene	0.60
DNMT1	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60
DLGAP2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
PENK	expressed_in	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GSH	associated_with	gene	0.60
HO1	associated_with	gene	0.60
PD-L1	therapeutic_target	gene	0.60
HGF	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
PPARG	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
PRKCA	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
NRF2	associated_with	gene	0.60
TNC	activates	gene	0.60
IBA1	activates	gene	0.60
SIRT1	activates	gene	0.60
BDNF	activates	gene	0.60
TGM2	associated_with	gene	0.60
GLS	activates	gene	0.60
DEMENTIA	associated_with	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
AMYLOID	associated_with	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AHR	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARG1 in their description or question text

No additional research found