disease

SCHIZOPHRENIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCHIZOPHRENIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1295Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	AKT, AMYLOID, APOE, BDNF, CACNA1G, CASP3, CLOCK, CYTOKINES
KG Connections	456 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

L23 Interneurons Schizophrenia

cell_type · 1515 words

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Pathway Diagram

graph TD
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"associated"| SYNGR1["SYNGR1"]
    style SYNGR1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| SLEEP["SLEEP"]
    style SLEEP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| SYNAPSE["SYNAPSE"]
    style SYNAPSE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| TEMPORAL_LOBE["TEMPORAL LOBE"]
    style TEMPORAL_LOBE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    RELN["RELN"] -->|"implicated in"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style RELN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S["ALZHEIMER'S"] -->|"causes"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style ALZHEIMER_S fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    PARKIN["PARKIN"] -->|"causes"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style PARKIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style SCHIZOPHRENIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (348)

Target	Relation	Type	Str
neurons	affects	cell_type	0.90
cortex	affects	brain_region	0.90
interneurons	affects	cell_type	0.90
Als	associated_with	disease	0.85
oxidative stress response	involves	pathway	0.80
serotonin	disrupts	neurotransmitter	0.80
NMDA receptor	involves	receptor	0.80
Synaptic Plasticity	associated_with	pathway	0.80
Depression	associated_with	disease	0.75
dopamine receptor	involves	receptor	0.70
nicotinic receptor	involves	receptor	0.70
pyramidal neurons	affects	cell_type	0.70
cerebellum	affects	brain_region	0.70
striatum	affects	brain_region	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
synaptic plasticity	involves	pathway	0.70
blood-brain barrier	affects	brain_region	0.70
thalamus	affects	brain_region	0.70
STING	regulates	gene	0.65
TH	inhibits	gene	0.65
Inflammation	associated_with	disease	0.65
DOPAMINE	regulates	phenotype	0.65
Alzheimer	associated_with	disease	0.65
CEREBELLUM	interacts_with	brain_region	0.65
Als	therapeutic_target	disease	0.65
Anxiety	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
STROKE	associated_with	disease	0.60
STING	contributes_to	gene	0.60
Mtor	therapeutic_target	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
Complement	inhibits	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
neuropeptide Y	disrupts	neurotransmitter	0.60
oxytocin	disrupts	neurotransmitter	0.60
muscarinic receptor	involves	receptor	0.60
microglia	affects	cell_type	0.60
cerebral cortex	affects	brain_region	0.60
ferroptosis	involves	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
temporal lobe	affects	brain_region	0.60
hypothalamus	affects	brain_region	0.60
prefrontal cortex	affects	brain_region	0.60
amygdala	affects	brain_region	0.60
glutamate signaling	involves	pathway	0.60
TH	associated_with	gene	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
nucleus accumbens	affects	brain_region	0.60
GABAergic neurons	affects	cell_type	0.60
neural stem cells	affects	cell_type	0.60

Incoming (947)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
dopamine signaling	implicated_in	pathway	0.95
Metabolism And Inflammation-Related Genes	involved_in	pathway	0.95
TNFSF	implicated_in	pathway	0.95
TNFSF	upregulates	pathway	0.95
PLA2G4A	risk_factor_for	gene	0.95
C4A	risk_factor_for	gene	0.93
Postsynaptic Interactomes	associated_with	pathway	0.90
Dopamine	associated_with	entity	0.90
Dopamine Signaling	associated_with	pathway	0.90
C4B	risk_gene_for	gene	0.90
RLN1	associated_with	protein	0.90
Tnf Receptor Inhibition	therapeutic_target	mechanism	0.85
mTOR-Dependent Autophagy Dysfunction	contributes_to	mechanism	0.85
Mtnr1B	therapeutic_target	protein	0.85
HDC	biomarker_for	gene	0.85
FUCA1	biomarker_for	gene	0.85
RELN	implicated_in	entity	0.85
Complement Activation	contributes_to	process	0.85
CX3CR1	biomarker_for	gene	0.85
NCKAP1L	biomarker_for	gene	0.85
CD40LG	biomarker_for	gene	0.85
SNAP25	biomarker_for	gene	0.85
Pla2 Superfamily	involved_in	protein	0.85
Haloperidol	risk_factor_for	drug	0.85
LCPUFA Deficiency	risk_factor_for	phenotype	0.85
DEPRESSION	associated_with	gene	0.85
OXIDATIVE STRESS	therapeutic_target	gene	0.85
Cpla2	involved_in	protein	0.85
Lipid Homeostasis	involved_in	process	0.85
RLN	associated_with	protein	0.85
Microbiota	associated_with	process	0.80
PLA2 Superfamily	involved_in	pathway	0.80
NPAS3	associated_with	gene	0.80
MICROBIOTA	implicated_in	biological_process	0.80
Cpla2	biomarker_for	biomarker	0.80
CHRFAM7A	associated_with	gene	0.80
Serotonin	associated_with	compound	0.80
REELIN	implicated_in	protein	0.80
Lipid Homeostasis	contributes_to	process	0.80
PLA2G12F	risk_factor_for	gene	0.80
PLA2G4F	risk_factor_for	gene	0.80
Reelin Signaling Pathway	associated_with	pathway	0.80
PLA2G4A	affects	gene	0.80
cytosolic phospholipase A2	biomarker_for	protein	0.80
Lcpufa Deficiency	causes	phenotype	0.80
MTOR Inhibitors	treats	drug	0.80
BIPOLAR DISORDER	associated_with	disease	0.80
ALZHEIMER'S DISEASE	interacts_with	disease	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCHIZOPHRENIA in their description or question text

No additional research found