gene

NTRK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTRK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

245Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Neurotrophic Receptor Tyrosine Kinase 2, BDNF receptor TrkB

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🧬 Gene Info

Gene Symbol	NTRK2
Full Name	Neurotrophic Receptor Tyrosine Kinase 2
Chromosome	9q22.1
Protein Type	Receptor
Function	encodes the BDNF (brain-derived neurotrophic factor) receptor, also known as TrkB
Pathways	PI3K, MAPK, mTOR
UniProt ID	Q16620
NCBI Gene ID	4915
Ensembl ID	ENSG00000148018
OMIM	600456
GeneCards	NTRK2
Human Protein Atlas	NTRK2
Associated Diseases	Alzheimer, Alzheimer's disease, disease
Interactions	ADCYAP1R1, ALZHEIMER, APOPTOSIS, ASTROCYTES, ATP1A2, Bdnf
KG Connections	245 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NTRK2 — AlphaFold Q16620 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NTRK2 Gene

gene · 2414 words

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Pathway Diagram

graph TD
    NTRK2["NTRK2"]
    FGF7["FGF7"]
    NTRK2 -->|"regulates"| FGF7
    Ms{"Ms"}
    NTRK2 -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    NTRK2 -->|"inhibits"| Carcinoma
    NTRK2 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    NTRK2 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    NTRK2 -->|"inhibits"| Tumor
    NTRK2 -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    NTRK2 -->|"interacts with"| Inflammation
    Schizophrenia{"Schizophrenia"}
    NTRK2 -->|"interacts with"| Schizophrenia
    BDNF["BDNF"]
    NTRK2 -->|"activates"| BDNF
    TRKB["TRKB"]
    NTRK2 -->|"activates"| TRKB
    PAK1["PAK1"]
    NTRK2 -->|"inhibits"| PAK1
    BDNF -->|"interacts with"| NTRK2
    BDNF -->|"activates"| NTRK2
    TRKB -->|"activates"| NTRK2
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| NTRK2
    TLR4["TLR4"]
    TLR4 -->|"associated with"| NTRK2
    CANCER["CANCER"]
    CANCER -->|"inhibits"| NTRK2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| NTRK2
    TNC["TNC"]
    TNC -->|"associated with"| NTRK2
    AND["AND"]
    AND -->|"activates"| NTRK2
    style NTRK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (156)

Target	Relation	Type	Str
Synaptic Clustering	mediates	process	0.95
Antidepressant Response	involved_in	phenotype	0.88
Adenosine A2A Receptor	interacts_with	receptor	0.82
FGF7	regulates	protein	0.70
Als	expressed_in	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	inhibits	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
SYNAPTIC PLASTICITY	regulates	phenotype	0.65
tau	co_discussed	concept	0.65
PI3K	co_discussed	gene	0.65
TNF	co_discussed	gene	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Obesity	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
PI3K	inhibits	gene	0.65
ALS	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
BDNF	encodes	gene	0.65
ALS	expressed_in	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
BDNF	associated_with	gene	0.65
FOS	activates	gene	0.60
CREB1	activates	gene	0.60
BDNF	expressed_in	gene	0.60
CALB2	inhibits	gene	0.60
CALB1	inhibits	gene	0.60
PVALB	inhibits	gene	0.60
S100B	activates	gene	0.60
GFAP	activates	gene	0.60
SCN4B	interacts_with	gene	0.60
NTF3	activates	gene	0.60
Neuron	associated_with	cell_type	0.60
Neuron	regulates	cell_type	0.60
Apoptosis	associated_with	pathway	0.60
BDNF	inhibits	gene	0.60
GAD1	inhibits	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
MAO	associated_with	gene	0.60
Ras	associated_with	protein	0.60
App	associated_with	protein	0.60

Incoming (89)

Source	Relation	Type	Str
H4	activates	hypothesis	0.00
BDNF	associated_with	protein	0.95
BDNF	upregulates	gene	0.88
BDNF	interacts_with	protein	0.70
NLRP3	co_discussed	gene	0.65
MAPT	co_discussed	gene	0.65
APOE	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
CDK5	co_discussed	gene	0.65
MIR-155	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURON	regulates	gene	0.60
ATP1A2	interacts_with	gene	0.60
MICRORNAS	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MAO	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
NLRP3	inhibits	gene	0.60
NLRP3	protects_against	gene	0.60
NLRP3	implicated_in	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
KIF5A	associated_with	gene	0.60
IL1	inhibits	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
BDNF	expressed_in	gene	0.60
TRKB	expressed_in	gene	0.60
miR-10a	regulates	mirna	0.60
S100B	activates	gene	0.60
ADCYAP1R1	interacts_with	gene	0.60
CLDN4	interacts_with	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	associated_with	gene	0.60
TNC	associated_with	gene	0.60
BDNF	inhibits	gene	0.60
GFAP	activates	gene	0.60
DGKQ	expressed_in	gene	0.60
TRKB	regulates	gene	0.60
GAD1	inhibits	gene	0.60
GFAP	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
NTF3	associated_with	gene	0.60
BDNF	regulates	gene	0.60
TRKB	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CLDN4	associated_with	gene	0.60
HUB GENES	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
TRKB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the minimum effective dose of trazodone required for disease-modifying e

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.605

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the minimum effective dose of trazodone required for disease-modifying e

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning NTRK2 in their description or question text

No additional research found