gene 822 words KG: NCAM1
Contents

NCAM1 Gene

🧬 Gene Info
Gene SymbolNCAM1
FunctionNCAM1 encodes a cell adhesion molecule essential for neural development and plasticity.
Molecular Weight220 kDa
PathwaysMAPK, PI3K
Ensembl IDENSG00000149294
GeneCardsNCAM1
Human Protein AtlasNCAM1
Cell adhesionMediates homophilic (NCAM-NCAM) and heterophilic interactions with other cell surface proteins
Neuronal migrationGuides neuronal precursors during brain development
Axon guidanceProvides directional cues for growing axons
SynaptogenesisPromotes formation and maintenance of synapses
Signal transductionActivates intracellular signaling through FGFR, p59fyn, and other kinases
Associated DiseasesAls, Bipolar, Depression, Ms, Schizophrenia
InteractionsAPOPTOSIS, CANCER, CDKN2A, COL4A1, DAO, DCC
KG Connections133 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Bipolar Cells in Visual Processing
cell · KG edge: associated_with
blarcamesine-axon
clinical_trial · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
AKT1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

HTR2A associated_with NCAM1
DISC1 associated_with NCAM1
FKBP5 associated_with NCAM1
NRG1 associated_with NCAM1
DAO associated_with NCAM1
BMAL1 associated_with NCAM1
GRM4 associated_with NCAM1
SYNGR1 associated_with NCAM1
BDNF associated_with NCAM1
NCAM1 associated_with RGS4

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