gene

GRM3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections
0Hypotheses
0Analyses
50Outgoing
44Incoming
0Experiments
0Debates

Summary

GRM3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, regulates. Associated with ALS, Als, Alzheimer. Connected to 69 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGRM3
Full NameGlutamate Metabotropic Receptor 3
Chromosome7q21.12
Protein FamilyClass C GPCR, mGluR family
Protein TypeReceptor
FunctionmGluR3 is a presynaptic autoreceptor and postsynaptic receptor that
Subcellular Localization**: Presynaptic and postsynaptic membranes
Molecular Weight98 kDa
Amino Acids879 aa
PathwaysMAPK, PI3K, NF-κB
UniProt IDQ14832
NCBI Gene ID2915
Ensembl IDENSG00000138821
OMIM604099
GeneCardsGRM3
Human Protein AtlasGRM3
Associated Diseasesaging, Als, Alzheimer, Bipolar
InteractionsDAO, DISC1, G72, GRIN2B, GRM4, NCAM1
KG Connections124 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GRM3 — AlphaFold Q14832 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GRM3 — Glutamate Metabotropic Receptor 3

gene · 867 words

mGluR3 (GRM3) Neurons

cell · 901 words

Pathway Diagram

flowchart TD
    GRM3["GRM3"] -->|"associated with"| Schizophrenia["Schizophrenia"]
    GRM3["GRM3"] -->|"associated with"| Als["Als"]
    GRM3["GRM3"] -->|"associated with"| Depression["Depression"]
    GRM3["GRM3"] -->|"associated with"| Bipolar["Bipolar"]
    GRM3["GRM3"] -->|"associated with"| Ms["Ms"]
    GRM3["GRM3"] -->|"expressed in"| Alzheimer["Alzheimer"]
    GRM3["GRM3"] -->|"expressed in"| Ms["Ms"]
    GRM3["GRM3"] -->|"expressed in"| Schizophrenia["Schizophrenia"]
    GRM3["GRM3"] -->|"associated with"| ALS["ALS"]
    GRM3["GRM3"] -->|"associated with"| Circadian_Rhythm["Circadian Rhythm"]
    GRM3["GRM3"] -->|"associated with"| DAO["DAO"]
    GRM3["GRM3"] -->|"associated with"| NRG1["NRG1"]
    style GRM3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Schizophrenia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Bipolar fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style Circadian_Rhythm fill:#1b5e20,stroke:#333,color:#e0e0e0
    style DAO fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NRG1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (80)

TargetRelationTypeStr
ALSassociated_withdisease0.65
Alzheimerexpressed_indisease0.65
Msexpressed_indisease0.65
Schizophreniaexpressed_indisease0.65
Schizophreniaassociated_withdisease0.65

Incoming (44)

SourceRelationTypeStr
AGINGassociated_withgene0.60
DEMENTIAregulatesgene0.60
HTR2Aassociated_withgene0.60
DISC1associated_withgene0.60
FKBP5associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRM3 in their description or question text

No additional research found