gene

FGF10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

21Outgoing

17Incoming

0Experiments

0Debates

Summary

FGF10 encodes a critical growth factor that promotes neural progenitor cell proliferation, neurogenesis, and brain development, with roles in neural regeneration, neuroprotection, and potential therapeutic applications in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	FGF10
Full Name	Fibroblast Growth Factor 10
Chromosome	5p12
Function	encodes a critical member of the fibroblast growth factor family that plays essential roles in embryonic development, tissue morphogenesis, and cellular proliferation.
Primary Expression	epithelial and neuronal tissues[@kumar1998]
Molecular Weight	23.4 kDa
Amino Acids	208 aa
UniProt ID	O15520
NCBI Gene ID	2255
Ensembl ID	ENSG00000164283
OMIM	602115
GeneCards	FGF10
Human Protein Atlas	FGF10
N-terminal signal peptide	Directs secretion
FGF core domain	Conserved 120-amino acid core
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	APOPTOSIS, CANCER, CD44, CDKN2A, COL4A1, CYTOKINES
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF10 — AlphaFold O15520 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FGF10 — Fibroblast Growth Factor 10

gene · 3796 words

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Pathway Diagram

graph TD
    FGF10["FGF10"]
    Carcinoma{"Carcinoma"}
    FGF10 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    FGF10 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    FGF10 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    FGF10 -->|"inhibits"| Tumor
    DLC1["DLC1"]
    FGF10 -->|"inhibits"| DLC1
    KCNH1["KCNH1"]
    FGF10 -->|"inhibits"| KCNH1
    NCAM1["NCAM1"]
    FGF10 -->|"inhibits"| NCAM1
    RGS1["RGS1"]
    FGF10 -->|"inhibits"| RGS1
    RAB27A["RAB27A"]
    FGF10 -->|"inhibits"| RAB27A
    COL4A1["COL4A1"]
    FGF10 -->|"inhibits"| COL4A1
    Apoptosis(["Apoptosis"])
    FGF10 -->|"inhibits"| Apoptosis
    Wnt(["Wnt"])
    FGF10 -->|"inhibits"| Wnt
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| FGF10
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| FGF10
    CANCER["CANCER"]
    CANCER -->|"inhibits"| FGF10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| FGF10
    TNC["TNC"]
    TNC -->|"inhibits"| FGF10
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| FGF10
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| FGF10
    WNT7A["WNT7A"]
    WNT7A -->|"inhibits"| FGF10
    LZTS1["LZTS1"]
    LZTS1 -->|"inhibits"| FGF10
    DCC["DCC"]
    DCC -->|"inhibits"| FGF10
    KCNK2["KCNK2"]
    KCNK2 -->|"inhibits"| FGF10
    CD44["CD44"]
    CD44 -->|"inhibits"| FGF10
    style FGF10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
RAB27A	inhibits	gene	0.60
COL4A1	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
DLC1	inhibits	gene	0.60
Mapk	inhibits	pathway	0.60
KCNH1	inhibits	gene	0.60
NCAM1	inhibits	gene	0.60
RGS1	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Immune Response	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Macrophage	inhibits	cell_type	0.60
Monocyte	inhibits	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
Dendritic Cell	inhibits	cell_type	0.60

Incoming (17)

Source	Relation	Type	Str
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-4	inhibits	gene	0.60
IL-13	inhibits	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
IRF7	inhibits	gene	0.60
ISG15	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF10 in their description or question text

No additional research found