gene

DCC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

0Analyses

50Outgoing

26Incoming

0Experiments

0Debates

Summary

DCC is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 42 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DCC
Full Name	Deleted in Colorectal Cancer
Chromosome	18q21.2
Protein Type	Receptor
Function	DCC is a member of the immunoglobulin superfamily of cell adhesion molecules and functions as the primary receptor for the axon guidance molecule netrin-1.
Primary Expression	the developing and adult central nervous system, where it plays essential roles in neuronal axon guidance, cell migration, synapse formation, and syna
Amino Acids	750 aa
Pathways	PI3K-AKT-mTOR signaling
UniProt ID	[Q9Y266](https://www.uniprot.org/uniprot/Q9Y266)
Ensembl ID	ENSG00000187323
OMIM	120470
GeneCards	DCC
Human Protein Atlas	DCC
Extracellular Domain	4 immunoglobulin (Ig) domains and 6 fibronectin type III (FNIII) repeats that mediate netrin-1 binding and cell adhesion
Transmembrane Domain	Single pass transmembrane helix
Associated Diseases	Als, cancer
Interactions	AKT, APOPTOSIS, CANCER, CD44, EPHA4, FGF10
KG Connections	83 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DCC["DCC"]
    Als{"Als"}
    DCC -->|"activates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DCC -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    DCC -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    DCC -->|"inhibits"| Carcinoma
    DCC -->|"inhibits"| Ms
    Cancer{"Cancer"}
    DCC -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    DCC -->|"inhibits"| Tumor
    GENES["GENES"]
    DCC -->|"activates"| GENES
    KCNK2["KCNK2"]
    DCC -->|"inhibits"| KCNK2
    CD44["CD44"]
    DCC -->|"inhibits"| CD44
    FGF10["FGF10"]
    DCC -->|"inhibits"| FGF10
    DLC1["DLC1"]
    DCC -->|"associated with"| DLC1
    EPHA4["EPHA4"]
    EPHA4 -->|"activates"| DCC
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| DCC
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| DCC
    CANCER["CANCER"]
    CANCER -->|"inhibits"| DCC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| DCC
    TNC["TNC"]
    TNC -->|"inhibits"| DCC
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| DCC
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| DCC
    WNT7A["WNT7A"]
    WNT7A -->|"associated with"| DCC
    LZTS1["LZTS1"]
    LZTS1 -->|"associated with"| DCC
    style DCC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Carcinoma	inhibits	disease	0.65
Carcinoma	contributes_to	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	associated_with	disease	0.65
AXON	regulates	gene	0.60
Neuron	associated_with	cell_type	0.60
PS1	inhibits	gene	0.60
PS1	associated_with	gene	0.60
KCNK2	inhibits	gene	0.60
CD44	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
DLC1	associated_with	gene	0.60
KCNH1	inhibits	gene	0.60
NCAM1	inhibits	gene	0.60
RGS1	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60
COL4A1	associated_with	gene	0.60
TRAF3	regulates	gene	0.60
ESR1	regulates	gene	0.60
FOXP2	regulates	gene	0.60
GRIA1	regulates	gene	0.60
GRM8	regulates	gene	0.60
NCAM1	regulates	gene	0.60
PDE4B	regulates	gene	0.60
cancer	associated_with	disease	0.60
MYC	causes	gene	0.60
AND	associated_with	gene	0.60
MEF2C	regulates	gene	0.60
EPHA5	regulates	gene	0.60
NLGN1	associated_with	gene	0.60
GENES	activates	gene	0.60
NGN2	regulates	gene	0.60
App	regulates	protein	0.60
BRCA1	associated_with	gene	0.60
Differentiation	causes	pathway	0.60
P53	associated_with	gene	0.60
RAS	causes	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Cell Cycle	causes	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Wnt	associated_with	pathway	0.60
Mapk	inhibits	pathway	0.60
PI3K	activates	gene	0.55

Incoming (26)

Source	Relation	Type	Str
CDKN2A	associated_with	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	associated_with	gene	0.60
LZTS1	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
NGN1	regulates	gene	0.60
NGN2	regulates	gene	0.60
MEF2C	regulates	gene	0.60
EPHA5	regulates	gene	0.60
NLGN1	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GENES	regulates	gene	0.60
EPHA4	activates	gene	0.60
NCAM1	regulates	gene	0.60
GRIA1	regulates	gene	0.60
GRM8	regulates	gene	0.60
ESR1	regulates	gene	0.60
PDE4B	regulates	gene	0.60
FOXP2	regulates	gene	0.60
CACNA1E	regulates	gene	0.60
AKT	activates	gene	0.55
APOE	associated_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DCC in their description or question text

No additional research found

DCC