gene

MITOCHONDRIAL DNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MITOCHONDRIAL DNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1239Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

MITOCHONDRIAL DNA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 869 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MITOCHONDRIAL DNA
Primary Expression	Spinal Cord, Substantia Nigra, Hippocampus
Pathways	Mitophagy, CGAS-STING, Autophagy, Cgas/Sting Dna Sensing Pathway, Nf-Κb
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Interactions	A2M, AGING, AHR, AIM2, AKT, ALS
KG Connections	1199 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"associated"| Alzheimer["Alzheimer"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"associated"| Als["Als"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"interacts"| Tumor["Tumor"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| Als_1["Als"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| Inflammation["Inflammation"]
    DHCR24["DHCR24"] -->|"interacts"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    EIF2AK2["EIF2AK2"] -->|"interacts"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    LMNA["LMNA"] -->|"interacts"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    STING["STING"] -->|"activates"| MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    style MITOCHONDRIAL_DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (796)

Target	Relation	Type	Str
mitochondrial DNA	encodes	protein	0.00
DNA	associated_with	gene	1.00
Als	activates	disease	1.00
DNA	activates	gene	1.00
Inflammation	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Mitochondrial Function	activates	pathway	1.00
Neurodegeneration	activates	disease	1.00
CANCER	activates	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
GENES	activates	gene	1.00
CGAS	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	activates	disease	1.00
MTDNA	activates	gene	1.00
MTDNA	associated_with	gene	1.00
Als	associated_with	disease	1.00
cGAS	activates	protein	1.00
Neurodegeneration	associated_with	disease	1.00
STING	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Mitophagy	activates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
MTDNA	causes	gene	1.00
DNA	inhibits	gene	1.00
Mitochondrial Function	therapeutic_target	pathway	1.00
CGAS-STING	activates	gene	1.00
GENES	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
DNA	causes	gene	1.00
Tumor	activates	disease	0.95
Als	inhibits	disease	0.95
Inflammation	associated_with	disease	0.95
Cancer	therapeutic_target	disease	0.95
Parkinson	activates	disease	0.95
cGAS-STING Pathway	activates	pathway	0.92
cGAS-STING pathway	activates	pathway	0.90
Cgas-Sting Pathway	activates	pathway	0.90
CGAS-STING	activates	pathway	0.90
cGAS/STING	activates	pathway	0.90
CGAS	activates	protein	0.90
AUTOPHAGY	activates	gene	0.90
Autophagy	activates	pathway	0.90
DRP1	activates	gene	0.90
Aging	therapeutic_target	disease	0.85
Diabetes	activates	disease	0.85
Aging	associated_with	disease	0.85
CGAS	activates	protein	0.85
Cgas	activates	protein	0.85

Incoming (443)

Source	Relation	Type	Str
MITOCHONDRIAL DNA	encodes	gene	0.00
NEURODEGENERATION	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
PINK1	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
TARDBP	associated_with	gene	0.95
TFAM	involved_in	gene	0.95
TFAM	binds	protein	0.95
TARDBP	causes	gene	0.95
oxidative stress	damages	process	0.90
41811415	is required for basal transcription of	paper	0.90
Mptp	mediates	mechanism	0.90
TDP-43	associated_with	protein	0.90
MAPL	transports	gene	0.90
TDP43	causes	entity	0.90
TDP-43	causes	protein	0.90
MPTP	mediates	protein	0.90
cGAS-STING Pathway	associated_with	pathway	0.90
MAPL	promotes	protein	0.90
ROS	activates	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
Mitophagy	associated_with	process	0.85
HSV-1	degrades	entity	0.85
1800 MHz radiofrequency radiation	induces_oxidative_damage	process	0.80
SOD1	regulates	gene	0.80
LRRK2	interacts_with	gene	0.80
Hsv-1	degrades	entity	0.80
FOXO3	downregulates	protein	0.80
TFAM	modulates	protein	0.80
TFAM	regulates	protein	0.80
PLD3	degrades	gene	0.80
TFAM	binds	protein	0.80
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.80
NEURODEGENERATIVE DISEASES	activates	gene	0.80
NF-ΚB	activates	gene	0.80
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.80
PARKINSON'S DISEASE	activates	gene	0.80
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.80
ROS	therapeutic_target	gene	0.80
INFLAMMATION	interacts_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
FERROPTOSIS	inhibits	gene	0.70
CYTOKINES	activates	gene	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
AUTOPHAGY	activates	gene	0.70

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.803	neurodegeneration	What are the mechanisms by which gut mic
Senescent Cell Mitochondrial DNA Release	0.742	neurodegeneration	Senolytic therapy for age-related neurod
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
Mitochondrial DNA Release-STING Axis as Senolytic Efficacy P	0.380	molecular biology	What is the optimal therapeutic window t

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000
Mixed Pathology Effects on Parkinson's Disease Progression and Treatme	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
NLRP3 Inflammasome Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Past, present and future perspectives on the science of aging. [PMID:41566049]	Fabrisia Ambrosio; Maxim N Artyomov; Ste	Nature aging	2026	0
Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757]	["Bi D", "Yang X", "Wang Y", "Yong J", "	Frontiers in immunology	2026	0
Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577]	["Zhou R", "Lin X", "Liao Z", "Lin J", "	Ageing research reviews	2026	0
Role of NEIL1 in genome maintenance. [PMID:40010204]	["McCullough A", "Minko I", "Luzadder M"	DNA repair	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808]	["Lai P", "Liu L", "Bancaro N", "Troiani	Immunity	2025	0
Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559]	["Akgun Y"]	Ageing research reviews	2025	0
Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226]	["Daubermann C", "Herhaus B", "Neuberger	Molecular biology reports	2025	0
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587]	["Song Z", "Xie X", "Chen Y", "Zhang B",	Immunity	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604]	["Orlikova-Boyer B", "Lorant A", "Gajula	Biomarker research	2024	0
Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919]	["Li X", "Liu Y", "Ke J", "Wang Z", "Han	Advanced materials (Deerfield	2024	0
The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400]	Zhang Y, Zou M, Wu H, Zhu J, Jin T	Neurobiology of disease	2024	0
mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044]	["Li Y", "Cui J", "Liu L", "Hambright W"	Cell death & disease	2024	0
Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958]	["Byrns C", "Perlegos A", "Miller K", "J	Nature	2024	0
Apoptotic stress causes mtDNA release during senescence and drives the SASP. [PMID:37821702]	["Victorelli S", "Salmonowicz H", "Chapm	Nature	2023	0
Exposome and unhealthy aging: environmental drivers from air pollution to occupa [PMID:37688657]	Pandics T, Major D, Fazekas-Pongor V, Sz	GeroScience	2023	0
Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438]	Hegdekar N, Sarkar C, Bustos S, Ritzel R	Autophagy	2023	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MITOCHONDRIAL DNA in their description or question text

No additional research found