concept

HISTONE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HISTONE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HISTONE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Histone Deacetylase (HDAC) Enzymes

entities · 1300 words

→

Pathway Diagram

graph TD
    HISTONE["HISTONE"]
    HISTONE -->|"involved_in"| Epigenomic_Reconfiguration["Epigenomic Reconfiguration"]
    HISTONE ---|"co-discussed"| MACROPHAGE["MACROPHAGE"]
    HISTONE ---|"co-discussed"| MACROPHAGES["MACROPHAGES"]
    HISTONE ---|"co-discussed"| LAMP1["LAMP1"]
    HISTONE ---|"co-discussed"| OCLN["OCLN"]
    HISTONE ---|"co-discussed"| P62["P62"]
    PROTAMINE["PROTAMINE"] -->|"interacts"| HISTONE
    DNA_METHYLATION["DNA METHYLATION"] ---|"co-discussed"| HISTONE
    EPIGENETIC["EPIGENETIC"] ---|"co-discussed"| HISTONE
    AUTOPHAGY["AUTOPHAGY"] ---|"co-discussed"| HISTONE
    BECN1["BECN1"] ---|"co-discussed"| HISTONE
    CREB["CREB"] ---|"co-discussed"| HISTONE

Outgoing (70)

Target	Relation	Type	Str
Epigenomic Reconfiguration	involved_in	process	0.90
Protamine	interacts_with	protein	0.88
Paternal genome reprogramming	contributes_to	process	0.80
TLR4	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
NEURONS	co_discussed	cell_type	0.50
SPINAL CORD	co_discussed	entity	0.50
SIRT1	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
INTERNEURON	co_discussed	entity	0.50
INTERNEURONS	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
PROTEOSTASIS	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
NLRP3	co_discussed	entity	0.50
UNFOLDED PROTEIN RESPONSE	co_discussed	entity	0.50
HSPA1A	co_discussed	entity	0.50
PREFRONTAL	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
MONOCYTE	co_discussed	entity	0.50
MONOCYTES	co_discussed	entity	0.50
SEROTONERGIC	co_discussed	entity	0.50
STAT3	co_discussed	entity	0.50
TBI	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
NFKB	co_discussed	entity	0.50
SNCA	co_discussed	entity	0.50
HSP90	co_discussed	entity	0.50
NEURON	co_discussed	cell_type	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
HTT	co_discussed	entity	0.50
LRP1	co_discussed	entity	0.50
PYROPTOSIS	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
LRRK2	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
INSULIN SIGNALING	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
LAMP1	co_discussed	entity	0.50
OCLN	co_discussed	entity	0.50

Incoming (57)

Source	Relation	Type	Str
PROTAMINE	interacts_with	entity	0.90
Protamine	interacts_with	protein	0.90
AMPK	co_discussed	entity	0.50
FERROPTOSIS	co_discussed	entity	0.50
GPX4	co_discussed	entity	0.50
CGAS	co_discussed	entity	0.50
EXCITOTOXICITY	co_discussed	entity	0.50
DEPRESSION	co_discussed	entity	0.50
GSK3B	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
CLU	co_discussed	entity	0.50
GABA	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
B CELL	co_discussed	entity	0.50
CASP1	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
CHOLINERGIC	co_discussed	entity	0.50
BACE1	co_discussed	entity	0.50
ERK	co_discussed	entity	0.50
C9ORF72	co_discussed	entity	0.50
APP	co_discussed	entity	0.50
DNA METHYLATION	co_discussed	entity	0.50
EPIGENETIC	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
BECN1	co_discussed	entity	0.50
CREB	co_discussed	entity	0.50
ATG7	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
GABAergic	co_discussed	entity	0.50
CD38	co_discussed	entity	0.50
DOPAMINERGIC	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
GRANULE CELL	co_discussed	entity	0.50
BLOOD-BRAIN BARRIER	co_discussed	entity	0.50
DENDRITIC SPINE	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
CIRCADIAN	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
AKT	co_discussed	entity	0.50
CHOLESTEROL	co_discussed	entity	0.50
BIN1	co_discussed	entity	0.50
GASDERMIN	co_discussed	entity	0.50
HIF1A	co_discussed	entity	0.50
ANGIOGENESIS	co_discussed	entity	0.50
GLUCOSE METABOLISM	co_discussed	entity	0.50
BBB	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp	0.520	neurodegeneration	Investigate mechanisms of epigenetic rep

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HISTONE in their description or question text

No additional research found