anatomical_structure

BBB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

141Connections

18Hypotheses

13Analyses

50Outgoing

29Incoming

11Experiments

15Debates

Summary

BBB is an entity related to neurodegeneration research. Key relationships include: co discussed, associated with, regulates. Associated with ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE. Connected to 70 entities in the SciDEX knowledge graph.

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Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BBB["Blood-Brain Barrier"] -->|"Components"| EC["Endothelial Cells"]
    BBB -->|"Components"| TJ["Tight Junctions"]
    BBB -->|"Components"| Pericytes["Pericytes"]
    BBB -->|"Components"| Astrocytes["Astrocytic End-feet"]
    EC -->|"Express"| Transporters["ABC Transporters"]
    TJ -->|"Seal"| Gaps["Paracellular Gaps"]
    BBB -->|"Regulates"| Influx["Nutrient Influx"]
    BBB -->|"Regulates"| Efflux["Waste Efflux"]
    Aging -.Causes.-> Breakdown["BBB Breakdown"]
    Breakdown -.Allows.-> Entry["Toxin Entry"]
    Entry -.Contributes to.-> ND["Neurodegeneration"]

Outgoing (112)

Target	Relation	Type	Str
WHITE MATTER	co_discussed	entity	0.50
ERK	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
MONOCYTE	co_discussed	entity	0.50
EPIGENETIC	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
VEGF	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
HYPOTHALAMUS	co_discussed	entity	0.50
PYCARD	co_discussed	entity	0.50
CHOLESTEROL	co_discussed	entity	0.50
LDLR	co_discussed	entity	0.50
SCHIZOPHRENIA	co_discussed	entity	0.50
HTT	co_discussed	entity	0.50
HUNTINGTON	co_discussed	entity	0.50
LC3	co_discussed	entity	0.50
FUS	co_discussed	entity	0.50
STRIATUM	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
BDNF	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
PICALM	co_discussed	entity	0.50
NECROPTOSIS	co_discussed	entity	0.50
RIPK1	co_discussed	entity	0.50
MITOPHAGY	co_discussed	entity	0.50
HIF1A	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
CLDN5	co_discussed	entity	0.50
BECN1	co_discussed	entity	0.50
MMP2	co_discussed	entity	0.50
MMP9	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
SPINAL CORD	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
BLOOD-BRAIN BARRIER	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
BRAINSTEM	co_discussed	entity	0.50
MYELINATION	co_discussed	entity	0.50
REMYELINATION	co_discussed	entity	0.50

Incoming (29)

Source	Relation	Type	Str
CLDN5	regulates	gene	0.90
autophagy	alleviates	process	0.90
CLDNs	disrupts	gene	0.80
CLAUDIN5	regulates	protein	0.72
HYPOXIA	causes	phenotype	0.72
AUTOPHAGY	regulates	pathway	0.72
Peripheral monocytes	traffics_across	cell_type	0.70
ENDOTHELIAL CELLS	protects_against	cell_type	0.65
STROKE	causes	disease	0.64
MONOCYTES	interacts_with	cell_type	0.64
ABCA1	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
AMPK	co_discussed	entity	0.50
ABETA	co_discussed	entity	0.50
APP	co_discussed	entity	0.50
B CELL	co_discussed	entity	0.50
BACE1	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
AQP4	co_discussed	entity	0.50
ANGIOGENESIS	co_discussed	entity	0.50
AKT	co_discussed	entity	0.50
ATG5	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50

Targeting Hypotheses (18)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VHH-Fc Fusion Constructs with Separate BBB-Targeting Moiety	0.750	neurodegeneration	Blood-brain barrier antibody transport m
Synthetic Biology BBB Endothelial Cell Reprogramming	0.727	neurodegeneration	Blood-brain barrier transport mechanisms
APOE4-driven pericyte injury/senescence is an upstream drive	0.720	neurodegeneration	Does pericyte senescence drive BBB break
Endothelial NRF2 Activation as a Master Switch for Post-CA B	0.689	neurodegeneration	View
BBB Integrity Loss Defines Absolute Therapeutic Window Closu	0.660	neurodegeneration	What is the optimal therapeutic window f

Time-Dependent BBB Repair Strategy	0.656	-	Blood-brain barrier tight junction disru
Pericyte senescence is sufficient to weaken the BBB even wit	0.630	neurodegeneration	Does pericyte senescence drive BBB break
P2RY12-driven autophagy impairment in cerebral VSMCs mediate	0.585	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
Vascular and Perivascular Cell Type Vulnerability: BBB Integ	0.566	neurodegeneration	Cell type vulnerability debate in Alzhei
BBB leak induces secondary pericyte senescence through TGF-b	0.560	neurodegeneration	Does pericyte senescence drive BBB break
Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytos	0.550	drug delivery	Can IGFBPL1 therapeutics effectively cro
Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complem	0.540	neuroinflammation	How does sevoflurane-induced NF-κB activ
Piezoelectric Nanochannel BBB Disruption	0.519	neurodegeneration	Blood-brain barrier transport mechanisms
CSF p-tau217 Normalization Requires Intact Synaptic Function	0.515	neurodegeneration	-
SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R	0.498	neuropharmacology	What determines blood-brain barrier pene
HBOT at 1.5 ATA for 90 days restores BBB integrity by upregu	0.460	neurodegeneration	What are the optimal oxygen pressure, du
IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability	0.420	drug delivery	Can IGFBPL1 therapeutics effectively cro
LRP1-Autophagy BBB Permeabilization for Antibody Transport	0.380	neurodegeneration	Blood-brain barrier antibody transport m

Mentioning Analyses (13)

Scientific analyses that reference this entity

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

neurodegeneration | 2026-04-26 | 0 hypotheses

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing of EMT states in SCC	exploratory	Skin squamous cell carcinoma	0.900	0.00	Primary mouse model	proposed	N/A
Gene expression analysis of autophagy targets following trehalose trea	exploratory	motoneuron degeneration	0.850	0.00	neuronal cell lines	proposed	N/A
Trehalose-induced autophagy gene expression analysis	exploratory	motoneuron degeneration	0.850	0.00	NSC34 neuroblastoma x spinal c	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic bas [PMID:36577758]	Gharbi Severine Isabelle; Pelletier Laur	NPJ breast cancer	2022
The biology of beauty sleep. [PMID:35256810]	Jordan A Anderson; Jenny Tung	Nature ecology & evolution	2022
Cathepsin S is a novel target for age-related dry eye. [PMID:34910926]	["Yu Z", "Li J", "Govindarajan G", "Hamm	Experimental eye research	2022
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867]	["Yu K", "Niu X", "Krook-Magnuson E", "H	Nature communications	2021
Warning wristbands for patients with intra-ocular gas [PMID:31745326]	Naderi Khayam; Masoero Pietro; Karthikey	Eye	2020
NK cells for cancer immunotherapy. [PMID:31907401]	["Shimasaki N", "Jain A", "Campana D"]	Nature reviews. Drug discovery	2020
Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636]	["Zhou W", "Ma L", "Yang J", "Qiao H", "	Cell death & disease	2019
Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373]	["Goswami S", "Peipert B", "Mongelli M",	Surgery	2019
Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403]	["Zhao Y", "Zhang Z", "Gao J", "Wang P",	Cell reports	2018
Cell transplantation therapy for spinal cord injury. [PMID:28440805]	["Assinck P", "Duncan G", "Hilton B", "P	Nature neuroscience	2017
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. [PMID:22343897]	["Ichimura A", "Hirasawa A", "Poulain-Go	Nature	2012

Debates (15)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

active · Rounds: 4 · Score: 0.73 · 2026-04-25

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

closed · Rounds: 4 · Score: 0.76 · 2026-04-23

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

closed · Rounds: 4 · Score: 0.81 · 2026-04-23

The debate highlighted IGFBPL1's potential as a microglial master regulator but

closed · Rounds: 4 · Score: 0.69 · 2026-04-22

The debate highlighted focused ultrasound as most feasible but didn't resolve cr

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

All participants identified BBB penetration as a critical bottleneck, but no exi

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

closed · Rounds: 4 · Score: 0.75 · 2026-04-16

All participants identified brain delivery as a critical barrier, but no mechani

closed · Rounds: 4 · Score: 0.50 · 2026-04-16

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

closed · Rounds: 7 · Score: 0.87 · 2026-04-16

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning BBB in their description or question text

BBB

Understanding Entity Pages

Summary

Wiki Pages (8)

neurovascular-dysfunction

BBB-Transcytosis Shuttle for Episodic CNS PROTAC Delivery

BBB Transcytosis Shuttle for Episodic CNS PROTAC Delivery

Focused Ultrasound BBB Opening

Brain Shuttle Technologies: BBB Delivery Platforms

AD BBB Modulation and Transport Technologies

Liver-Brain Axis - Hepatic Enzyme-Mediated BBB Protection

BBB-Penetrant Antibody Engineering

Pathway Diagram

Outgoing (112)

Incoming (29)

Targeting Hypotheses (18)

Mentioning Analyses (13)

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What determines blood-brain barrier penetration kinetics for specialized pro-res

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

What is the optimal BBB opening duration and spatial precision to maximize thera

What delivery mechanisms can achieve therapeutically relevant CRISPR concentrati

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

Senescent cell clearance as neurodegeneration therapy

Blood-brain barrier transport mechanisms for antibody therapeutics

Experiments (11)

Related Papers (11)

Debates (15)

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

The debate highlighted IGFBPL1's potential as a microglial master regulator but

The debate highlighted focused ultrasound as most feasible but didn't resolve cr

All participants identified BBB penetration as a critical bottleneck, but no exi

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

All participants identified brain delivery as a critical barrier, but no mechani

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

Related Research

Time-Dependent BBB Repair Strategy

Pericyte senescence is sufficient to weaken the BBB even without classic amyloid

P2RY12-driven autophagy impairment in cerebral VSMCs mediates BBB breakdown and

Vascular and Perivascular Cell Type Vulnerability: BBB Integrity Disruption

BBB leak induces secondary pericyte senescence through TGF-beta-dominant stress

Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytosis

Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complement Translocation

Piezoelectric Nanochannel BBB Disruption

SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precur

HBOT at 1.5 ATA for 90 days restores BBB integrity by upregulating claudin-5 and

IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability

LRP1-Autophagy BBB Permeabilization for Antibody Transport