concept

PREFRONTAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PREFRONTAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

4Hypotheses

0Analyses

31Outgoing

50Incoming

11Experiments

0Debates

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💡 Concept Info

Name	PREFRONTAL
Related Diseases	ALS, ANXIETY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

prefrontal-cortex-circuits

circuit · 2272 words

→

Pathway Diagram

graph TD
    PREFRONTAL["PREFRONTAL"]
    PREFRONTAL -->|"regulates"| SOD1["SOD1"]
    PREFRONTAL -->|"regulates"| PTSD["PTSD"]
    PREFRONTAL -->|"causes"| SUBSTANTIA_NIGRA["SUBSTANTIA NIGRA"]
    PREFRONTAL -->|"causes"| VENTRAL_TEGMENTAL["VENTRAL TEGMENTAL"]
    ALS["ALS"] -->|"regulates"| PREFRONTAL
    C9ORF72["C9ORF72"] -->|"regulates"| PREFRONTAL
    FUS["FUS"] -->|"regulates"| PREFRONTAL
    AMYLOID["AMYLOID"] -->|"reduces"| PREFRONTAL
    HIPPOCAMPUS["HIPPOCAMPUS"] -->|"contributes to"| PREFRONTAL
    FRONTAL["FRONTAL"] -->|"sensitizes_to"| PREFRONTAL
    CORTEX["CORTEX"] -->|"regulates"| PREFRONTAL

Outgoing (31)

Target	Relation	Type	Str
SOD1	regulates	gene	0.65
PTSD	regulates	disease	0.60
VENTRAL TEGMENTAL	causes	brain_region	0.60
SUBSTANTIA NIGRA	causes	brain_region	0.60
STING	co_discussed	entity	0.50
PYRAMIDAL	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
PSD95	co_discussed	entity	0.50
STAT3	co_discussed	entity	0.50
TFEB	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
SMPD1	co_discussed	entity	0.50
SPHINGOLIPID	co_discussed	entity	0.50
PYROPTOSIS	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
TLR4	co_discussed	entity	0.50
PSEN1	co_discussed	entity	0.50
SQSTM1	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
SYNAPTIC TRANSMISSION	co_discussed	biological_process	0.40
SCHIZOPHRENIA	co_discussed	disease	0.40
PTSD	co_discussed	disease	0.40
STRIATUM	co_discussed	brain_region	0.40

Incoming (117)

Source	Relation	Type	Str
C9ORF72	regulates	gene	0.65
FUS	regulates	gene	0.65
ALS	regulates	disease	0.65
CORTEX	regulates	brain_region	0.65
ALS	sensitizes_to	disease	0.65
FRONTAL	associated_with	brain_region	0.65
HIPPOCAMPUS	associated_with	brain_region	0.65
INTERNEURONS	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
CORTEX	inhibits	brain_region	0.60
FRONTAL	inhibits	brain_region	0.60
INTERNEURON	inhibits	cell_type	0.60
INTERNEURONS	inhibits	cell_type	0.60
NEURON	inhibits	cell_type	0.60
NEURONS	inhibits	cell_type	0.60
CORTEX	associated_with	brain_region	0.60
CHRNA7	expressed_in	gene	0.60
INTERNEURON	activates	cell_type	0.60
CORTEX	causes	brain_region	0.60
DOPAMINERGIC	causes	cell_type	0.60
GFAP	activates	gene	0.60
FRONTAL	causes	brain_region	0.60
AMYGDALA	regulates	brain_region	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
FRONTAL	regulates	brain_region	0.60
HIPPOCAMPUS	regulates	brain_region	0.60
CORTEX	activates	brain_region	0.60
DEPRESSION	activates	disease	0.60
FRONTAL	activates	brain_region	0.60
FRONTAL	mediates	brain_region	0.60
MICROGLIA	expressed_in	cell_type	0.60
DRD2	mediates	gene	0.60
CORTEX	mediates	brain_region	0.60
DEPRESSION	expressed_in	disease	0.60
ANXIETY	expressed_in	disease	0.60
DEMENTIA	regulates	disease	0.60
DRD2	regulates	gene	0.60
NEURON	contributes_to	cell_type	0.60
CORTEX	expressed_in	brain_region	0.60
FRONTAL	expressed_in	brain_region	0.60
DOPAMINERGIC	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
DLB	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.785	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
CHI3L1 variant association with AD progression in human patients	exploratory	Alzheimer's disease	0.850	0.00	human patients	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Integrated multimodal cell atlas of Alzheimer’s disease [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nature Neuroscience	2024	225
Transcriptional and functional profiles of muscarinic receptor-expressing neuron [PMID:41857244]	Tsolias A, Mojica CA, Yamani R, Khanna S	Communications biology	2026	0
Neurophysiological and neuropharmacological effects of melatonin MT2 receptors a [PMID:41571206]	["Barzon B", "Marchiotto F", "Nasini S",	Biochemical pharmacology	2026	0
Enhanced interhemispheric functional connectivity in elderly anxiety patients wi [PMID:41656398]	["Chang Y", "Liu M", "Liu Y", "Xie X", "	Scientific reports	2026	0
Convergent transcriptomic and connectomic controllers of information integration [PMID:41606107]	Luppi AI, Uhrig L, Tasserie J, Mediano P	Nature human behaviour	2026	0
Transcranial direct current stimulation restores addictive behavior via prefront [PMID:41136747]	["Zuo H", "Zhang W", "Wang L", "Wu Y", "	Molecular psychiatry	2026	0
Meta-Analyses of Auditory Evoked Potentials as Alzheimer Biomarkers. [PMID:40836165]	Bayat A, Mirmomeni G, Aiken S, Jafari Z	Ear and hearing	2026	0
Establishing mouse forebrain organoids as models of intrinsic cortical network a [PMID:41791384]	Hernandez S, Schweiger HE, Cline I, Kaur	Stem cell reports	2026	0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026	0
A silent Kv channel subunit shapes PV neuron action potential waveform and short [PMID:41632839]	Ganesh S, Canty TM, Sabatini BL	Proceedings of the National Ac	2026	0
Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomati [PMID:41279752]	Mandal P, Trushina E, Arnold M, Kaddurah	bioRxiv : the preprint server	2025	0
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025	0
Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Pre [PMID:40426616]	["Liu W", "Li N", "Tang D", "Qin L", "Zh	Brain sciences	2025	0
Medial prefrontal cortex circuit dynamics involved in stage-specific addiction. [PMID:41307570]	["Zhao D", "Zhang X", "Bai J"]	Brain structure & function	2025	0
Studies in rats of a target specific and reversible general anesthetic with a fa [PMID:41187127]	["Xie Z", "Fong R", "Fox A"]	PloS one	2025	0
tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lob [PMID:40874060]	["Han Y", "Dong A", "Xia C", "Zhang Z",	Frontiers in behavioral neuros	2025	0
Fate plasticity of interneuron specification. [PMID:40264797]	["Mostajo-Radji M", "Leon W", "Breevoort	iScience	2025	0
The thalamic reticular nucleus orchestrates social memory. [PMID:38701789]	Wang F, Sun H, Chen M, Feng B, Lu Y, Lyu	Neuron	2024	0
A vagal reflex evoked by airway closure. [PMID:38448588]	["Schappe M", "Brinn P", "Joshi N", "Gre	Nature	2024	0
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PREFRONTAL in their description or question text

No additional research found