concept

B CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

538Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

B CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with GLIOBLASTOMA, LYMPHOMA, TUMOR. Connected to 30 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	B CELL
Key Genes/Proteins	AMPK, AQP4, BCL2
Related Diseases	CANCER

Pathway Diagram

graph TD
    B_CELL["B CELL"]
    TCR["TCR"] -->|"expressed in"| B_CELL
    CD40["CD40"] -->|"expressed in"| B_CELL
    CANCER["CANCER"] -->|"expressed in"| B_CELL
    AQP4["AQP4"] -->|"expressed in"| B_CELL
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_CELL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| B_CELL
    CD19["CD19"] -->|"expressed in"| B_CELL
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| B_CELL
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"expressed in"| B_CELL
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| B_CELL

Outgoing (128)

Target	Relation	Type	Str
ST6Gal1	expressed_in	enzyme	0.90
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.90
Igg	expressed_in	protein	0.90
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.90
Aqp4-Igg	associated_with	biomarker	0.88
Neuromyelitis optica spectrum disorder activity	biomarker_for	disease	0.80
CANCER	inhibits	disease	0.65
LYMPHOMA	causes	disease	0.65
P53	inhibits	gene	0.65
BCL2	regulates	gene	0.65
NEUTROPHIL	increases	cell_type	0.65
LYMPHOMA	reduces	disease	0.65
IL-6	inhibits	gene	0.65
NEURONS	activates	cell_type	0.60
MACROPHAGE	regulates	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
MONOCYTE	promotes	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
CHAT	activates	gene	0.60
NEURON	activates	cell_type	0.60
TUMOR	inhibits	disease	0.60
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
STING	causes	gene	0.60
MYC	activates	gene	0.60
LYMPHOMA	inhibits	disease	0.60
GFAP	activates	gene	0.60
ERK	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
OCLN	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
GFAP	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
ST6GAL1	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
FUT8	associated_with	concept	0.50
ST6GAL1	activates	concept	0.50
FUT8	activates	concept	0.50
Immunotherapy	activates	process	0.50
B CELLS	activates	concept	0.50
Spinal Cord	expressed_in	brain_region	0.50
Brainstem	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
BDNF	co_discussed	entity	0.50
SIRT6	co_discussed	entity	0.50
FOXO3	co_discussed	entity	0.50

Incoming (410)

Source	Relation	Type	Str
Inebilizumab	downregulates	drug	0.90
AMPK	activates	gene	0.65
CD19	biomarker_for	gene	0.60
AQP4	inhibits	gene	0.60
JUN	therapeutic_target	gene	0.60
IRF4	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
DNA	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
TLR	activates	gene	0.60
ROS	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CD4	associated_with	gene	0.60
FOS	therapeutic_target	gene	0.60
GJA1	therapeutic_target	gene	0.60
CCL2	therapeutic_target	gene	0.60
RNA	biomarker_for	gene	0.60
DEMENTIA	activates	gene	0.60
TDP-43	activates	gene	0.60
ALS	activates	gene	0.60
IL-1	activates	gene	0.60
CHAT	activates	gene	0.60
RPA1	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
MRPS31	therapeutic_target	gene	0.60
TIMMDC1	therapeutic_target	gene	0.60
LYRM7	therapeutic_target	gene	0.60
PGS1	therapeutic_target	gene	0.60
BCS1L	therapeutic_target	gene	0.60
FBXO7	therapeutic_target	gene	0.60
EPOR	activates	gene	0.60
TYK2	activates	gene	0.60
CRLF2	activates	gene	0.60
FLT3	activates	gene	0.60
JAK2	activates	gene	0.60
IL7R	activates	gene	0.60
ABL2	activates	gene	0.60
TSLP	activates	gene	0.60
CSF1R	activates	gene	0.60
AQP4	activates	gene	0.60
DR5	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
TRAIL	therapeutic_target	gene	0.60
BCL-2	therapeutic_target	gene	0.60
NDUFAF7	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELL in their description or question text

No additional research found