concept

B CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

B CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with GLIOBLASTOMA, LYMPHOMA, TUMOR. Connected to 30 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	B CELL
Key Genes/Proteins	AMPK, AQP4, BCL2
Related Diseases	CANCER

Pathway Diagram

graph TD
    B_CELL["B CELL"]
    TCR["TCR"] -->|"expressed in"| B_CELL
    CD40["CD40"] -->|"expressed in"| B_CELL
    CANCER["CANCER"] -->|"expressed in"| B_CELL
    AQP4["AQP4"] -->|"expressed in"| B_CELL
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_CELL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| B_CELL
    CD19["CD19"] -->|"expressed in"| B_CELL
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| B_CELL
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"expressed in"| B_CELL
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| B_CELL

Outgoing (128)

Target	Relation	Type	Str
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.90
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.90
ST6Gal1	expressed_in	enzyme	0.90
Igg	expressed_in	protein	0.90
Aqp4-Igg	associated_with	biomarker	0.88
Neuromyelitis optica spectrum disorder activity	biomarker_for	disease	0.80
BCL2	regulates	gene	0.65
LYMPHOMA	causes	disease	0.65
CANCER	inhibits	disease	0.65
P53	inhibits	gene	0.65
IL-6	inhibits	gene	0.65
NEUTROPHIL	increases	cell_type	0.65
LYMPHOMA	reduces	disease	0.65
TUMOR	inhibits	disease	0.60
STING	causes	gene	0.60
LYMPHOMA	inhibits	disease	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
GFAP	activates	gene	0.60
T CELLS	activates	cell_type	0.60
MYC	activates	gene	0.60
MONOCYTE	promotes	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
T CELL	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
CHAT	activates	gene	0.60
NEURONS	co_discussed	cell_type	0.50
GENE EXPRESSION	expressed_in	concept	0.50
B CELLS	expressed_in	concept	0.50
DNA DAMAGE	regulates	concept	0.50
Microrna	regulates	pathway	0.50
Dna Damage Response	regulates	pathway	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
B CELLS	interacts_with	concept	0.50
MACROPHAGES	activates	concept	0.50
SENESCENCE	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
JAK	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
LAMP1	co_discussed	entity	0.50
CSF1R	co_discussed	entity	0.50
CGAS	co_discussed	entity	0.50
CASP1	co_discussed	entity	0.50
HISTONE	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50

Incoming (409)

Source	Relation	Type	Str
Inebilizumab	downregulates	drug	0.90
AMPK	activates	gene	0.65
IRF4	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
IBA1	activates	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
MICROGLIA	activates	gene	0.60
DNA	regulates	gene	0.60
TLR7	therapeutic_target	gene	0.60
PARP1	inhibits	gene	0.60
IL-10	inhibits	gene	0.60
IFN	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
TLR	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
AMPK	activates	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
EGR2	inhibits	gene	0.60
CXCR3	activates	gene	0.60
C1QA	activates	gene	0.60
CCL20	activates	gene	0.60
LRP1	activates	gene	0.60
YY1	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
PARKINSON	activates	gene	0.60
SIRT6	inhibits	gene	0.60
CD38	activates	gene	0.60
ERK	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
SYNAPSE	activates	gene	0.60
TNF	activates	gene	0.60
NAD	activates	gene	0.60
CD38	inhibits	gene	0.60
CXCR4	activates	gene	0.60
FUT8	transports	gene	0.60
RPA1	regulates	gene	0.60
JUN	therapeutic_target	gene	0.60
MICRORNAS	regulates	gene	0.60
CHAT	activates	gene	0.60
CASPASE8	inhibits	gene	0.60
EHMT2	inhibits	gene	0.60
BAX	inhibits	gene	0.60
CASPASE3	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
FOXO1	inhibits	gene	0.60
JUN	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.738	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELL in their description or question text

No additional research found