biological_process

ANGIOGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANGIOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1200Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Biological Process Info

Name	ANGIOGENESIS
Key Genes/Proteins	AKT, AMYLOID
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, ASTHMA

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Angiogenesis Pathway

mechanism · 1518 words

→

Pathway Diagram

graph TD
    ANGIOGENESIS["ANGIOGENESIS"] -->|"associated"| CANCER["CANCER"]
    style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| STING["STING"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"activates"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| CELL_MIGRATION["CELL MIGRATION"]
    style CELL_MIGRATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    NTN1["NTN1"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style NTN1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| ANGIOGENESIS["ANGIOGENESIS"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"co discussed"| ANGIOGENESIS["ANGIOGENESIS"]
    style AKT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    CYTOKINES["CYTOKINES"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style CYTOKINES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    STING_1["STING"] -->|"activates"| ANGIOGENESIS["ANGIOGENESIS"]
    style STING_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ANGIOGENESIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (220)

Target	Relation	Type	Str
Bone Fracture Healing	involved_in	process	0.95
Wound Healing	contributes_to	process	0.95
Wound Healing	involved_in	process	0.95
Brain Development	involved_in	process	0.95
Brain Tumors	associated_with	disease	0.90
Brain Vascular Malformations	associated_with	disease	0.90
Fracture Healing	contributes_to	process	0.90
ENDOTHELIAL CELLS	regulates	cell_type	0.80
VEGF	interacts_with	entity	0.70
ENDOTHELIAL CELLS	associated_with	cell_type	0.65
EGF	inhibits	gene	0.60
apoptosis	associated_with	pathway	0.60
oxidative stress	activates	process	0.60
CLOCK	binds_to	gene	0.60
PIEZO1	activates	gene	0.60
neuroinflammation	binds_to	process	0.60
MMP2	inhibits	gene	0.60
CX3CR1	activates	gene	0.60
NPM1	activates	gene	0.60
CLOCK	regulates	gene	0.60
AQP1	activates	gene	0.60
AQP1	regulates	gene	0.60
SRPK1	phosphorylates	gene	0.60
MMP9	inhibits	gene	0.60
AKT	activates	gene	0.58
Glycolysis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Notch	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Adaptive Immunity	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
ALZHEIMER'S DISEASE	depleted_in	disease	0.55
Epigenetic	interacts_with	pathway	0.55
APOE	co_discussed	entity	0.50
MITOPHAGY	co_discussed	entity	0.50
APP	co_discussed	entity	0.50
BACE1	co_discussed	entity	0.50
Alzheimer's Disease	associated_with	disease	0.50
LRP1	co_discussed	entity	0.50
DEMYELINATION	co_discussed	entity	0.50
Schizophrenia	associated_with	disease	0.50
RELN	co_discussed	entity	0.50
EXCITOTOXICITY	co_discussed	entity	0.50
BBB	co_discussed	entity	0.50
MYELINATION	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
MMP2	co_discussed	entity	0.50

Incoming (980)

Source	Relation	Type	Str
Tumor	regulates	disease	1.00
MTOR	therapeutic_target	gene	1.00
PI3K	therapeutic_target	gene	1.00
AKT	therapeutic_target	gene	1.00
Tumor	therapeutic_target	disease	1.00
STAT3	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
GENES	activates	gene	1.00
GENES	regulates	gene	1.00
Cancer	therapeutic_target	disease	1.00
PI3K	activates	gene	1.00
Ischemia	activates	disease	1.00
Tumor	activates	disease	1.00
INFLAMMATION	inhibits	gene	1.00
AKT	regulates	gene	1.00
CANCER	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
Als	activates	disease	1.00
AKT	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Als	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
Als	therapeutic_target	disease	1.00
PI3K	regulates	gene	1.00
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
Inflammation	inhibits	disease	1.00
APOPTOSIS	inhibits	gene	1.00
CANCER	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	inhibits	disease	1.00
Cancer	regulates	disease	1.00
CANCER	regulates	gene	1.00
Als	regulates	disease	1.00
MTOR	regulates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
PI3K	inhibits	gene	1.00
AKT	inhibits	gene	1.00
CYTOKINES	therapeutic_target	gene	1.00
AUTOPHAGY	regulates	gene	1.00
Inflammation	regulates	disease	1.00
CYTOKINES	activates	gene	1.00
VEGF	activates	gene	1.00
TNF	activates	gene	1.00
TNF-Α	activates	gene	1.00
MICRORNAS	regulates	gene	1.00
FGF2 MUTANT K119E/R120E	inhibits	protein	0.95
IRISIN	associated_with	protein	0.95

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANGIOGENESIS in their description or question text

No additional research found