gene

CD38

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

621Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

CD38 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 290 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD38
Chromosome	4p15.32
Protein Type	Enzyme
Target Class	Enzyme
Function	cADPR acts as a potent second messenger that releases calcium from intracellular stores (endoplasmic reticulum) through ryanodine receptors[@guse2005].
Mechanism of Action	Monoclonal antibody targeting or small molecule inhibitor of NAD+ consuming activity
Primary Expression	various tissues including brain cells (neurons, astrocytes, microglia) and plays important roles in neuro
Druggability	Medium (0.61)
Clinical Stage	Approved
Amino Acids	301 aa
Pathways	Cerebrovascular, Circadian Rhythm, Differentiation, Immune Response, Mitochondrial Function
UniProt ID	H0Y950
Ensembl ID	ENSG00000104419
GeneCards	CD38
Human Protein Atlas	CD38
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	nicotinamide, NICOTINAMIDE
Interactions	Actin, AGING, AND, APOE, APOPTOSIS, App
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	CD38 Inhibition for NAD+ Restoration and Microglia
KG Connections	612 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — CD38 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1YH3 — X-ray / Cryo-EM

🔮 AI Predicted Structure

H0Y950 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD38["CD38"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CD38["CD38"] -->|"interacts"| NAMPT["NAMPT"]
    CD38["CD38"] -->|"co discussed"| C1Q["C1Q"]
    CD38["CD38"] -->|"co discussed"| NAMPT_1["NAMPT"]
    CD38["CD38"] -->|"co discussed"| GPX4["GPX4"]
    CD38["CD38"] -->|"co discussed"| PLA2G6["PLA2G6"]
    NAMPT_2["NAMPT"] -->|"interacts"| CD38["CD38"]
    MMP9["MMP9"] -->|"co discussed"| CD38["CD38"]
    SLC7A11["SLC7A11"] -->|"co discussed"| CD38["CD38"]
    AQP4["AQP4"] -->|"co discussed"| CD38["CD38"]
    style CD38 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (460)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD38	data_in	dataset_row	0.00
Lysosomal Cholesterol Efflux	associated_with	process	0.95
Neurons	expressed_in	cell_type	0.90
Microglial Cells	expressed_in	cell_type	0.90
Astrocytes	expressed_in	cell_type	0.90
Neurodegeneration	associated_with	process	0.85
mitochondrial transfer	associated_with	process	0.85
ADENOSINERGIC PATHWAY	involved_in	entity	0.85
Immune Response	associated_with	process	0.85
Nad	regulates	compound	0.85
nad	regulates	protein	0.85
Neuroinflammation	involved_in	process	0.85
Nad	catalyzes	compound	0.85
purinergic signaling	regulates	pathway	0.85
Mitochondrial Transfer	mediates	mechanism	0.85
mitochondrial transfer	mediates	process	0.85
neurodegeneration	contributes_to	phenotype	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
APOPTOSIS	suppresses	process	0.80
programmed cell death	inhibits	process	0.80
NAD metabolism	involved_in	pathway	0.80
NAMPT	associated_with	gene	0.80
NAD+ metabolism	regulates	pathway	0.80
Aging	inhibits	disease	0.75
Inflammation	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Inflammation	activates	disease	0.75
ATP production	regulates	process	0.75
MIRO1	interacts_with	gene	0.75
microglia	expressed_in	cell_type	0.72
astrocytes	expressed_in	cell_type	0.72
neurons	expressed_in	cell_type	0.72
NOTCH	activates	gene	0.70
MACROPHAGE	associated_with	cell_type	0.70
FOXP3	regulates	gene	0.70
STING	mediates	gene	0.70
MICROGLIA	expresses	cell_type	0.70
TNF	activates	gene	0.70
CX3CR1	associated_with	gene	0.70
MACROPHAGE	regulates	cell_type	0.70
NEURONS	expressed_in	cell_type	0.70
MACROPHAGE	markers	cell_type	0.70
SIRT1	activates	gene	0.70
Parkinson's disease	protects_against	disease	0.70
NAD+ levels	inhibits	biomarker	0.70
NAD	associated_with	gene	0.70
unfolded protein response	participates_in	pathway	0.70
macrophages	activates	cell_type	0.70
neural stem cells	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70

Incoming (161)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD38	data_in	dataset_row	0.00
GJ-PD	upregulates	drug	0.90
h-cb833ed8	targets	hypothesis	0.90
Aging	upregulates	process	0.80
GJ-PD herbal pair	upregulates	drug	0.80
Geum japonicum Thunb. var. chinense-Potentilla decorata H. Andres	upregulates	drug	0.80
SDA-2026-04-01-gap-013	targets	analysis	0.80
ASTROCYTE	expressed_in	cell_type	0.70
APOE	causes	gene	0.70
CCL2	associated_with	gene	0.70
ASTROCYTE	protects_against	cell_type	0.70
NAD	inhibits	gene	0.70
CANCER	associated_with	gene	0.70
NAD	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
NAMPT	interacts_with	gene	0.64
aging	activates	phenotype	0.64
STAT3	activates	gene	0.60
BDNF	activates	gene	0.60
CD206	activates	gene	0.60
DNA	associated_with	gene	0.60
AD	markers	gene	0.60
AD	co_discussed	gene	0.60
ASTROCYTE	inhibits	cell_type	0.60
ASTROCYTES	inhibits	cell_type	0.60
ASTROCYTE	regulates	cell_type	0.60
NAMPT	inhibits	gene	0.60
SIRT6	inhibits	gene	0.60
EGR2	activates	gene	0.60
PARP1	inhibits	gene	0.60
P2RY1	associated_with	gene	0.60
PANX1	associated_with	gene	0.60
NAMPT	regulates	gene	0.60
SIRT1	regulates	gene	0.60
NAMPT	associated_with	gene	0.60
CCR1	regulates	gene	0.60
MRC1	regulates	gene	0.60
C1QB	regulates	gene	0.60
CXCL12	expressed_in	gene	0.60
SRC	expressed_in	gene	0.60
CXCR4	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
LYSOSOME	activates	gene	0.60
IL-6	activates	gene	0.60
LDL	activates	gene	0.60
AGING	inhibits	gene	0.60
ALZHEIMER'S DISEASE	co_discussed	disease	0.60
APOPTOSIS	inhibits	pathway	0.60
CD33	causes	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD38 Inhibition for NAD+ Restoration and Microglial Senescen	0.575	neurodegeneration	Microglial subtypes in neurodegeneration

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CD38 in their description or question text

No additional research found

CD38

Understanding Entity Pages

Summary

Wiki Pages (3)

CD38 Molecule (CD38)

CD38 Inhibition + NAD+ Precursor Synergy for Neuroprotection

CD38 Inhibitor Therapy for Neurodegeneration

Pathway Diagram

Outgoing (460)

Incoming (161)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Microglial subtypes in neurodegeneration — friend vs foe

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Mitochondrial transfer between astrocytes and neurons

Senolytic therapy for age-related neurodegeneration

Experiments (0)

Related Papers (0)

Debates (4)

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Mitochondrial transfer between astrocytes and neurons

Related Research