protein

NMDA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for NMDA Receptor Subunit NR2B (GRIN2B)

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🔬 Protein Info

Gene Symbol	NMDA
Aliases	GRIN2B, GRIN1
Molecular Weight	166 kDa
Pathways	glutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism
GeneCards	NMDA
Human Protein Atlas	NMDA
Working memory	Maintenance and manipulation of information over seconds to minutes, requiring sustained activity in layer 3 pyramidal neurons
Cognitive control	Top-down modulation of attention and stimulus processing, suppressing prepotent responses
Task-set shifting	Flexible adaptation of behavioral rules based on changing contingencies
Planning and problem-solving	Sequential organization of complex, multi-step behaviors
Monitoring and error detection	Tracking performance against internal goals, signal processing via anterior cingulate interactions
Layer II/IV (granular layers)	Relatively more spared early, but receive the thalamocortical inputs that drive arousal-driven task engagement.
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, disease, epilepsy, Huntington
Known Drugs/Compounds	memantine
Interactions	ABCA7, AMPA RECEPTOR, AMYLOID, AND, APP, ATP
KG Connections	213 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NMDA["NMDA"]
    SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
    NMDA -->|"associated with"| SYNAPTOPHYSINSYP
    Memantine["Memantine"]
    Memantine -->|"activates"| NMDA
    Memantine -->|"inhibits"| NMDA
    GLUTAMATE["GLUTAMATE"]
    GLUTAMATE -->|"co discussed"| NMDA
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"co discussed"| NMDA
    ALZHEIMER_S["ALZHEIMER'S"]
    ALZHEIMER_S -->|"co discussed"| NMDA
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"co discussed"| NMDA
    style NMDA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
glutamate signaling	participates_in	pathway	0.85
PSD-95	associated_with	gene	0.75
neurons	expressed_in	cell_type	0.75
oxidative stress response	participates_in	pathway	0.65
PSD-95	interacts_with	gene	0.65
unfolded protein response	participates_in	pathway	0.65
neurodegeneration	activates	disease	0.65
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
neurodegeneration	inhibits	disease	0.60
pyroptosis	participates_in	pathway	0.60
VPS35	interacts_with	gene	0.60
stroke	regulates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
epilepsy	causes	disease	0.60
schizophrenia	causes	disease	0.60
epilepsy	associated_with	disease	0.60
stroke	associated_with	disease	0.60
SQSTM1	regulates	gene	0.60
Alzheimer's disease	regulates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
epilepsy	inhibits	disease	0.60
NMDAR	causes	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
neuroinflammation	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
neuroinflammation	inhibits	disease	0.60
microglia	expressed_in	cell_type	0.60
PSD95	targets	gene	0.55
astrocytes	expressed_in	cell_type	0.55
mitochondrial function	participates_in	pathway	0.55
Alzheimer's disease	inhibits	disease	0.55
TET2	activates	gene	0.55
ROS	activates	gene	0.55
oligodendrocytes	expressed_in	cell_type	0.55
neurotrophin signaling	participates_in	pathway	0.55
PSD95	expressed_in	gene	0.55
Alzheimer's disease	expressed_in	disease	0.55
sphingolipid metabolism	participates_in	pathway	0.55
tauopathy	expressed_in	disease	0.55
epilepsy	activates	disease	0.55
SLC17A7	activates	gene	0.55
synaptic plasticity	participates_in	pathway	0.55
MAPK signaling	participates_in	pathway	0.55
NEURON	contributes_to	entity	0.50
S100A8	co_expressed_with	gene	0.50
S100A9	co_expressed_with	gene	0.50

Incoming (107)

Source	Relation	Type	Str
Memantine	inhibits	entity	0.70
Memantine	activates	entity	0.70
AND	inhibits	gene	0.60
LRRK2	interacts_with	gene	0.60
AND	regulates	gene	0.60
APOE	associated_with	gene	0.60
NLRP3	activates	gene	0.60
LAMP2B	regulates	gene	0.60
memantine	targets	drug	0.60
APP	inhibits	gene	0.60
CRH	associated_with	gene	0.60
EAAT2	inhibits	gene	0.60
CCL2	activates	gene	0.60
GAPDH	regulates	gene	0.60
HDAC6	regulates	gene	0.60
ISG15	regulates	gene	0.60
LAMP1	regulates	gene	0.60
LC3	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
MAPT	regulates	gene	0.60
ABCA7	activates	gene	0.60
GABA	activates	gene	0.60
BAX	activates	gene	0.55
JNK	activates	gene	0.55
ATP	activates	gene	0.55
NLGN1	interacts_with	gene	0.55
BAK	activates	gene	0.55
MAPT	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
NFKB	co_discussed	entity	0.50
BBB	co_discussed	entity	0.50
ISCHEMIA	co_discussed	entity	0.50
MITOPHAGY	co_discussed	entity	0.50
DREBRIN	regulates	protein	0.50
GRIN2A	activates	gene	0.50
Neurodegeneration	inhibits	disease	0.50
ATP	co_expressed_with	protein	0.50
GRIN2D	co_expressed_with	protein	0.50
AQP4	co_expressed_with	gene	0.50
EAAT2	co_expressed_with	protein	0.50
APP	co_expressed_with	gene	0.50
BDNF	co_expressed_with	gene	0.50
B CELL	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
NLRP3	co_discussed	entity	0.50
EXCITOTOXICITY	co_discussed	entity	0.50
ERK	co_discussed	entity	0.50
GABAergic	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Thalamocortical Synchrony Restoration via NMDA Modulation	0.728	neuroscience	Circuit-level neural dynamics in neurode
Cortico-Striatal Synchrony Restoration via NMDA Modulation	0.723	neuroscience	Circuit-level neural dynamics in neurode
Fyn-anchored dendritic tau/NMDAR signaling persists after tr	0.670	neurodegeneration	Does tau dendritic missorting persist in
Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau	0.620	neurodegeneration	Investigate prion-like spreading of tau

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Inspired by molecular dynamic simulation, exploring chemical constituents of alc [PMID:40166865]	Shinge J, Muthal A, Walhekar V, Bagul C,	Journal of biomolecular struct	2026
Cognitive loss after brain trauma results from sex-specific activation of synapt [PMID:40796363]	Arizanovska D, Bush GF, Dallera CA, Folo	Brain	2026
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil. [PMID:40994429]	Banke TG, Regan MC, Perszyk RE, Zhang L,	Brain	2026
GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and beha [PMID:41512078]	Ge Y, Tian T, Li B, Axerio-Cillies P, Ch	Sci Adv	2026
Zipper-interacting Protein Kinase Modulates Gene Expression Linked to Synaptic a [PMID:41526727]	Mei Y, Zheng L, He M, Wang L, Zhou Y et	Mol Neurobiol	2026
Multi-biofluid metabolomics coupled with gene network reveals stage-specific alt [PMID:41534821]	Cadaxo AS, Cotrin JC, Valente AP, Lopes	Brain Res	2026
Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mi [PMID:41675057]	Farsi Z, Nicolella A, Simmons SK, Shin W	iScience	2026
From synapse to system: mechanistic pathways of neural signaling dysfunction in [PMID:41799440]	Gupta R, Jha NK, Kumar N, Nagraik R, Rav	Front Cell Dev Biol	2026
Multisession epidural direct current stimulation of the auditory cortex mitigate [PMID:41747412]	Fernández Del Campo IS, Cebrián-León A,	Hearing research	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NMDA in their description or question text

No additional research found

NMDA

Understanding Entity Pages

Summary

Wiki Pages (20)

Dorsolateral Prefrontal Cortex Executive Dysfunction in Alzheimer's Disease

GRIN1 — NMDA Receptor Subunit 1

Anti-NMDA Receptor Encephalitis

NMDA Receptor

GRIN2A Protein (NMDA Receptor Subunit 2A)

NMDA Receptor

Memantine - NMDA Antagonist for Alzheimer's Disease

NMDA Receptor Neurons

NR2B (GluN2B) NMDA Receptor Subunit

GRIN2C Gene - Glutamate Ionotropic Receptor NMDA Type Subunit 2C

NR3A (NMDA Receptor Subunit)

NR3B (NMDA Receptor Subunit)

GRIN2B — NMDA Receptor Subunit 2B

NMDA Receptor Protein

NMDA Receptor Subunit NR2B (GRIN2B)

Anti-NMDA Receptor Encephalitis-Affected Neurons

NMDA Receptor NR2A Protein

NMDA Receptor Subunit NR1 (GRIN1)

GRIN3B Gene — NMDA Receptor Subunit 3B

GRIN2C Protein - NR2C NMDA Receptor Subunit