concept

GABAERGIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABAERGIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

199Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	GABAERGIC
Key Genes/Proteins	ACHE, AD, ADAM10, AMPK, APOE, APP
Related Diseases	ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE
Related Pathways	APOPTOSIS, AUTOPHAGY

Pathway Diagram

graph TD
    GABAERGIC["GABAERGIC"]
    GABAERGIC -->|"inhibits"| GLUTAMATERGIC["GLUTAMATERGIC"]
    GABAERGIC -->|"inhibits"| NEURON["NEURON"]
    GABAERGIC -->|"inhibits"| NEURONS["NEURONS"]
    GABAERGIC -->|"inhibits"| NEUROTRANSMISSION["NEUROTRANSMISSION"]
    GABAERGIC -.protects against.-> MICROGLIA["MICROGLIA"]
    GABAERGIC -->|"targets"| INTERNEURON["INTERNEURON"]
    CA1["CA1"] -->|"inhibits"| GABAERGIC
    DOPAMINERGIC["DOPAMINERGIC"] -->|"regulates"| GABAERGIC
    CORTEX["CORTEX"] -->|"targets"| GABAERGIC
    ALZHEIMER["ALZHEIMER"] -.protects against.-> GABAERGIC
    ALZHEIMER_S["ALZHEIMER'S"] -.protects against.-> GABAERGIC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.protects against.-> GABAERGIC
    AMYLOID["AMYLOID"] -->|"targets"| GABAERGIC

Outgoing (127)

Target	Relation	Type	Str
LRP1	stabilizes	gene	0.70
GLUTAMATERGIC	interacts_with	cell_type	0.70
OLIGODENDROCYTE	causes	cell_type	0.70
OLIGODENDROCYTE	regulates	cell_type	0.70
STING	associated_with	gene	0.70
NOTCH	transports	gene	0.70
SLC6A4	regulates	gene	0.70
HTR2A	regulates	gene	0.70
GLUTAMATERGIC	regulates	cell_type	0.70
STING	activates	gene	0.70
MMP9	transports	gene	0.70
RELN	activates	gene	0.70
NEURONS	mediates	cell_type	0.70
GLUTAMATERGIC	mediates	cell_type	0.70
NEURONS	transports	cell_type	0.70
STING	inhibits	gene	0.70
GLUTAMATERGIC	expresses	cell_type	0.70
GABRA1	activates	gene	0.70
NEURONS	interacts_with	cell_type	0.70
RAGE	causes	gene	0.70
NEURON	associated_with	cell_type	0.65
NEURON	protects_against	cell_type	0.65
NEURONS	protects_against	cell_type	0.65
RAPAMYCIN	regulates	drug	0.65
NEURONS	causes	cell_type	0.65
NEURON	causes	cell_type	0.65
INTERNEURON	biomarker_for	cell_type	0.65
INTERNEURON	inhibits	cell_type	0.65
GLUTAMATERGIC	inhibits	cell_type	0.65
NEURON	inhibits	cell_type	0.65
NEURONS	inhibits	cell_type	0.65
INTERNEURON	associated_with	cell_type	0.60
INTERNEURONS	associated_with	cell_type	0.60
PURKINJE	associated_with	cell_type	0.60
T CELL	contributes_to	cell_type	0.60
NEURON	disrupts	cell_type	0.60
NEURON	biomarker_for	cell_type	0.60
NEURONS	biomarker_for	cell_type	0.60
GLUTAMATERGIC	biomarker_for	cell_type	0.60
HIPPOCAMPUS	biomarker_for	brain_region	0.60
GLUTAMATERGIC	associated_with	cell_type	0.60
NEURON	regulates	cell_type	0.60
NEURONS	associated_with	cell_type	0.60
INTERNEURON	expressed_in	cell_type	0.60
INTERNEURONS	expressed_in	cell_type	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
LRP1	causes	gene	0.60
LRP1	regulates	gene	0.60
NEURONS	regulates	cell_type	0.60
NEUROINFLAMMATION	regulates	pathway	0.60

Incoming (72)

Source	Relation	Type	Str
CHOLINERGIC	regulates	cell_type	0.70
ASTROCYTE	causes	cell_type	0.70
ADAM10	activates	gene	0.70
ASTROCYTE	regulates	cell_type	0.70
CHRNA7	regulates	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
ACHE	regulates	gene	0.70
DOPAMINERGIC	activates	cell_type	0.70
APOE	activates	gene	0.70
DOPAMINERGIC	regulates	cell_type	0.65
CORTEX	targets	brain_region	0.65
AMPK	associated_with	gene	0.65
CA1	inhibits	brain_region	0.65
AUTOPHAGY	regulates	pathway	0.60
DYRK1A	regulates	gene	0.60
AD	activates	gene	0.60
AD	co_discussed	gene	0.60
AΒ	expresses	gene	0.60
AD	protects_against	gene	0.60
ALZHEIMER'S DISEASE	enhances	disease	0.60
APOPTOSIS	regulates	pathway	0.60
ALZHEIMER	expressed_in	disease	0.60
ALZHEIMER'S	expressed_in	disease	0.60
ALZHEIMER'S DISEASE	expressed_in	disease	0.60
CORTEX	biomarker_for	brain_region	0.60
CEREBELLUM	promotes	brain_region	0.60
CHOLINERGIC	biomarker_for	cell_type	0.60
DOPAMINERGIC	inhibits	cell_type	0.60
ALZHEIMER	protects_against	disease	0.60
ALZHEIMER'S	protects_against	disease	0.60
ALZHEIMER'S DISEASE	protects_against	disease	0.60
APP	targets	gene	0.60
CORTEX	activates	brain_region	0.60
DEPRESSION	inhibits	disease	0.60
DOPAMINERGIC	associated_with	cell_type	0.60
APP	enhances	gene	0.60
APP	regulates	gene	0.60
APP	causes	gene	0.60
APOE	enhances	gene	0.60
DRD2	expresses	gene	0.60
ASTROCYTES	causes	cell_type	0.60
ACHE	co_discussed	gene	0.60
BDNF	regulates	gene	0.60
BDNF	activates	gene	0.60
AD	inhibits	gene	0.60
AD	regulates	gene	0.60
AΒ	disrupts	gene	0.60
ASTROCYTES	associated_with	cell_type	0.60
APP	co_discussed	entity	0.50
DOPAMINERGIC	co_discussed	entity	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocytic APOE4 Disruption of GABAergic Support Increasing	0.450	neurodegeneration	How does APOE4 mechanistically increase
GABAergic Hub Stabilization Through α5-Subunit Inverse Agoni	0.430	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABAERGIC in their description or question text

No additional research found