gene

KDR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

29Outgoing

26Incoming

0Experiments

0Debates

Summary

KDR (VEGFR2) - Kinase Insert Domain Receptor regulating angiogenesis, neurovascular coupling, and neurodegeneration

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🧬 Gene Info

Gene Symbol	KDR
Aliases	VEGFR2
Chromosome	4q12
Protein Type	Receptor
Function	is a receptor tyrosine kinase that serves as the primary signaling receptor for VEGF-mediated angiogenesis and vascular development.
Molecular Weight	230 kDa
Amino Acids	356 aa
Exons	30
Pathways	Function
GeneCards	KDR
Human Protein Atlas	KDR
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AND, HDAC9, ICAM1, MMP2, MMP9, NANOG
KG Connections	55 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KDR Gene

gene · 1564 words

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VEGFR2 (KDR) Protein

protein · 558 words

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Pathway Diagram

graph TD
    KDR["KDR"]
    Inflammation{"Inflammation"}
    KDR -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    KDR -->|"therapeutic target"| Ms
    Fibrosis{"Fibrosis"}
    KDR -->|"biomarker for"| Fibrosis
    Diabetes{"Diabetes"}
    KDR -->|"biomarker for"| Diabetes
    Als{"Als"}
    KDR -->|"biomarker for"| Als
    KDR -->|"biomarker for"| Ms
    MMP9["MMP9"]
    KDR -->|"inhibits"| MMP9
    ICAM1["ICAM1"]
    KDR -->|"inhibits"| ICAM1
    SPP1["SPP1"]
    KDR -->|"inhibits"| SPP1
    Angiogenesis(["Angiogenesis"])
    KDR -->|"inhibits"| Angiogenesis
    MMP2["MMP2"]
    KDR -->|"inhibits"| MMP2
    NOS2["NOS2"]
    KDR -->|"inhibits"| NOS2
    RAGE["RAGE"]
    RAGE -->|"therapeutic target"| KDR
    SERPINE1["SERPINE1"]
    SERPINE1 -->|"inhibits"| KDR
    NOS2 -->|"inhibits"| KDR
    MMP2 -->|"inhibits"| KDR
    PTGS2["PTGS2"]
    PTGS2 -->|"inhibits"| KDR
    ICAM1 -->|"inhibits"| KDR
    MMP9 -->|"inhibits"| KDR
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"therapeutic target"| KDR
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic target"| KDR
    CD44["CD44"]
    CD44 -->|"biomarker for"| KDR
    IGF1["IGF1"]
    IGF1 -->|"biomarker for"| KDR
    EGF["EGF"]
    EGF -->|"biomarker for"| KDR
    style KDR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Inflammation	therapeutic_target	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	therapeutic_target	disease	0.65
Ulcerative Colitis	therapeutic_target	disease	0.65
ICAM1	inhibits	gene	0.60
SPP1	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
MMP9	inhibits	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mapk	associated_with	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
HRAS	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
POU5F1	activates	gene	0.60
Mapk	biomarker_for	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
DIABETES MELLITUS	biomarker_for	gene	0.60
FN1	biomarker_for	gene	0.60
NANOG	activates	gene	0.60
MMP2	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
FGF9	biomarker_for	gene	0.60
HSPG2	biomarker_for	gene	0.60
RAGE	therapeutic_target	gene	0.60

Incoming (26)

Source	Relation	Type	Str
AND	inhibits	gene	0.60
SPP1	inhibits	gene	0.60
RAGE	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
MAP2K1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
MAPK1	associated_with	gene	0.60
AKT	therapeutic_target	gene	0.60
MAPK14	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
HDAC9	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	biomarker_for	gene	0.60
ICAM1	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
CD44	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
EGF	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDR in their description or question text

No additional research found