gene

PIK3CG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

44Outgoing

21Incoming

0Experiments

0Debates

Summary

PIK3CG encodes the p110γ catalytic subunit of class IB PI3K, critical for immune cell signaling and neuroinflammation. It's an emerging therapeutic target for Parkinson's and Alzheimer's disease through modulation of microglial activation.

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🧬 Gene Info

Gene Symbol	PIK3CG
Full Name	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Chromosome	7q22.3
Protein Type	Receptor
Function	is a key signaling molecule in this process
Primary Expression	hematopoietic cells including macrophages, neutrophils, T cells, and B cells [1](https://doi
Pathways	PI3K, PI3K signaling
UniProt ID	P48736
NCBI Gene ID	5295
Ensembl ID	ENSG00000110676
OMIM	601298
GeneCards	PIK3CG
Human Protein Atlas	PIK3CG
p84/p101 regulatory subunits	PIK3CG requires association with either p84 (PIK3R5) or p101 (PIK3R6) for membrane localization and activity
PTEN	The phosphatase counteracting PI3Kγ by converting PIP3 back to PIP2
Associated Diseases	Als, Alzheimer, Dementia, Ms
Interactions	AKT, APOPTOSIS, BAX, BCL2, CANCER, CASPASE3
KG Connections	65 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PIK3CG — AlphaFold P48736 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3CG Gene

gene · 2542 words

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Pathway Diagram

graph TD
    PIK3CG["PIK3CG"]
    Alzheimer{"Alzheimer"}
    PIK3CG -->|"associated with"| Alzheimer
    Ms{"Ms"}
    PIK3CG -->|"associated with"| Ms
    Dementia{"Dementia"}
    PIK3CG -->|"associated with"| Dementia
    Als{"Als"}
    PIK3CG -->|"associated with"| Als
    neurodegeneration["neurodegeneration"]
    PIK3CG -->|"implicated in"| neurodegeneration
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_DISEASE -->|"associated with"| PIK3CG
    PRKCB["PRKCB"]
    PRKCB -->|"associated with"| PIK3CG
    style PIK3CG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Leukemia	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Akt	associated_with	pathway	0.60
Pi3K	activates	pathway	0.60
Mapk	associated_with	pathway	0.60
INS	activates	gene	0.60
GENES	activates	gene	0.60
KRAS	therapeutic_target	gene	0.60
Akt	activates	pathway	0.60
HRAS	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
RAGE	activates	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
MAPK	associated_with	gene	0.60
EGFR	therapeutic_target	gene	0.60
ERK	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
Apoptosis	activates	pathway	0.60
MAPK8	associated_with	gene	0.60
BCL2	activates	gene	0.60
MAPK1	associated_with	gene	0.60
PI3K	activates	gene	0.60
PPARG	regulates	gene	0.60
TNF	regulates	gene	0.60
EGFR	associated_with	gene	0.60
BAX	activates	gene	0.60
IGF1	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (21)

Source	Relation	Type	Str
ALZHEIMER DISEASE	associated_with	gene	0.60
PI3K	activates	gene	0.60
SRC	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
AKT	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	therapeutic_target	gene	0.60
AR	regulates	gene	0.60
GABRA6	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENES	treats	gene	0.60
PRKCB	associated_with	gene	0.60
CASPASE3	activates	gene	0.60
HSP90AA1	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
MAPK8	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3CG in their description or question text

No additional research found