gene

KCNH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

33Outgoing

16Incoming

0Experiments

0Debates

Summary

KCNH2 — Potassium Voltage-Gated Channel Subfamily H Member 2

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🧬 Gene Info

Gene Symbol	KCNH2
Full Name	Potassium Voltage-Gated Channel Subfamily H Member 2
Protein Type	Channel
Function	The S4 segment serves as the voltage sensor, while the S5-S6 pore region forms the ion conduction pathway.
Primary Expression	various regions including the hippocampus, cortex, thalamus, and basal ganglia
Ensembl ID	ENSG00000196878
GeneCards	KCNH2
Human Protein Atlas	KCNH2
Associated Diseases	ALS, epilepsy, Long-Qt Syndrome, Long QT Syndrome
Interactions	GABRG2, HCN1
KG Connections	49 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNH2 — Potassium Voltage-Gated Channel Subfamily H Member 2

gene · 875 words

→

KCNH2 Protein — Potassium Voltage-Gated Channel

protein · 797 words

→

Pathway Diagram

graph TD
    KCNH2["KCNH2"]
    Als{"Als"}
    KCNH2 -->|"therapeutic target"| Als
    Cardiac{"Cardiac"}
    KCNH2 -->|"therapeutic target"| Cardiac
    Ms{"Ms"}
    KCNH2 -->|"therapeutic target"| Ms
    IDH1["IDH1"]
    KCNH2 -->|"therapeutic target"| IDH1
    TP53["TP53"]
    KCNH2 -->|"therapeutic target"| TP53
    SCN5A["SCN5A"]
    KCNH2 -->|"therapeutic target"| SCN5A
    IL1B["IL1B"]
    KCNH2 -->|"therapeutic target"| IL1B
    KCNQ1["KCNQ1"]
    KCNH2 -->|"therapeutic target"| KCNQ1
    TNF["TNF"]
    KCNH2 -->|"therapeutic target"| TNF
    CALM1["CALM1"]
    KCNH2 -->|"therapeutic target"| CALM1
    LMNA["LMNA"]
    KCNH2 -->|"therapeutic target"| LMNA
    ACHE["ACHE"]
    KCNH2 -->|"therapeutic target"| ACHE
    style KCNH2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:KCNH2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Long-Qt Syndrome	associated_with	disease	0.99
Kv11.1 Channel	encodes	protein	0.99
Long QT Syndrome	causes	disease	0.95
SUDEP	risk_factor_for	disease	0.95
Premature Mortality	contributes_to	phenotype	0.88
Sudden Unexpected Death in Epilepsy	risk_factor_for	disease	0.85
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
ACHE	therapeutic_target	gene	0.60
SCN5A	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CALM1	therapeutic_target	gene	0.60
LMNA	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
Calcium Signaling	therapeutic_target	pathway	0.60
Complement	therapeutic_target	pathway	0.60
Circadian Rhythm	therapeutic_target	pathway	0.60
SYNAPSE	therapeutic_target	gene	0.60
Camp Signaling	therapeutic_target	pathway	0.60
Synaptic Transmission	therapeutic_target	pathway	0.60
ALS	associated_with	disease	0.60
epilepsy	associated_with	disease	0.60
IDH1	therapeutic_target	gene	0.60

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:KCNH2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
GABRG2	interacts_with	gene	0.85
HCN1	interacts_with	gene	0.85
EPILEPSY	associated_with	gene	0.70
AND	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
CALM1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNH2 in their description or question text

No additional research found