gene

PIK3R1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

373Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PIK3R1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Als, Alzheimer, Cancer. Connected to 168 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIK3R1
Full Name	Phosphoinositide-3-Kinase Regulatory Subunit 1
Aliases	PIK3R1 p85α regulatory subunit of PI3K
Chromosome	5q13.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	85 kDa
Amino Acids	724 aa
Pathways	PI3K, mTOR, mtor, PI3K pathway
GeneCards	PIK3R1
Human Protein Atlas	PIK3R1
Associated Diseases	Aging, Als, Alzheimer, Cancer, Fibrosis
Interactions	AGING, Akt, AKT, AKT1, ALZHEIMER, AND
KG Connections	373 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PIK3R1 Gene

gene · 841 words

→

PIK3R1 Protein (p85α)

protein · 1183 words

→

Pathway Diagram

graph TD
    PIK3R1["PIK3R1"]
    PIK3R1 -->|"regulates"| adipocyte_function["adipocyte function"]
    PIK3R1 -.biomarker for.-> Alzheimer["Alzheimer"]
    PIK3R1 -.biomarker for.-> Als["Als"]
    PIK3R1 -->|"target for"| Cancer["Cancer"]
    PIK3R1 -->|"target for"| Tumor["Tumor"]
    PIK3R1 -->|"activates"| Ms["Ms"]
    PIK3R1 -->|"regulates"| Glioblastoma["Glioblastoma"]
    IKBKB["IKBKB"] -.biomarker for.-> PIK3R1
    BNIP3["BNIP3"] -->|"regulates"| PIK3R1
    BCL2["BCL2"] -->|"regulates"| PIK3R1
    CTSL["CTSL"] -->|"regulates"| PIK3R1
    FOXO3["FOXO3"] -->|"target for"| PIK3R1
    BCL2_FAMILY["BCL2 FAMILY"] -->|"regulates"| PIK3R1
    CANCER["CANCER"] -->|"target for"| PIK3R1
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| PIK3R1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| PIK3R1
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"] -->|"regulates"| PIK3R1

Outgoing (205)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PIK3R1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
adipocyte function	regulates	phenotype	0.80
Als	activates	disease	0.75
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Als	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	causes	disease	0.65
Fibrosis	causes	disease	0.65
Ms	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	activates	disease	0.65
Cancer	implicated_in	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	activates	disease	0.65
Metabolic Syndrome	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	regulates	disease	0.65
Sepsis	activates	disease	0.65
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Als	causes	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cancer	regulates	disease	0.65
ALS	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Depression	activates	disease	0.65
Als	inhibits	disease	0.65
ALS	causes	disease	0.65
Senescence	activates	disease	0.65
HIF	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
Neuron	activates	cell_type	0.60
AXON	regulates	gene	0.60

Incoming (168)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PIK3R1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
PI3K	targets	gene	0.70
EGFR	targets	gene	0.70
PIK3CA	targets	gene	0.70
AKT	therapeutic_target	gene	0.70
DIABETES MELLITUS	regulates	gene	0.60
GENES	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
INS	activates	gene	0.60
ANXA5	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MAPK	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
WTAP	expressed_in	gene	0.60
ANXA5	regulates	gene	0.60
MAPK	regulates	gene	0.60
ESR1	therapeutic_target	gene	0.60
CANCER	implicated_in	gene	0.60
APOE	associated_with	gene	0.60
ESR1	regulates	gene	0.60
HRAS	regulates	gene	0.60
MAPK14	regulates	gene	0.60
MMP9	regulates	gene	0.60
TP53	regulates	gene	0.60
NF1	regulates	gene	0.60
TP53	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
EGF	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
PI3K	activates	gene	0.60
BAX	activates	gene	0.60
CTSB	regulates	gene	0.60
FOXO1	therapeutic_target	gene	0.60
EIF2AK2	therapeutic_target	gene	0.60
HIF1A	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
BECN1	regulates	gene	0.60
STAT3	regulates	gene	0.60
PIK3CG	therapeutic_target	gene	0.60
RAGE	activates	gene	0.60
RHOA	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
DNA	implicated_in	gene	0.60
NOS3	therapeutic_target	gene	0.60
ANGPT1	inhibits	gene	0.60
AKT	causes	gene	0.60
MAPK3	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3R1 in their description or question text

No additional research found