protein

GALC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GALC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

39Outgoing

5Incoming

0Experiments

0Debates

Summary

GALC is a protein involved in neurodegeneration research. Key relationships include: activates, contributes to, interacts with. Associated with Als, Cancer, Ms. Connected to 22 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GALC
Full Name	Galactocerebrosidase
Chromosome	14q31.3 (Chr14: 87,934,475-88,013,430)
Function	GALC encodes galactocerebrosidase, a lysosomal hydrolase that catalyzes the hydrolysis of galactocerebroside, a major lipid component of myelin.
Primary Expression	brain white matter, peripheral nerves
Molecular Weight	80 kDa
Pathways	Tgf-Β
UniProt ID	P54803
NCBI Gene ID	2581
Ensembl ID	ENSG00000135837
OMIM	245000
GeneCards	GALC
Human Protein Atlas	GALC
Medial motor column	Innervates axial/trunk muscles
Lateral motor column	Innervates limb muscles
Associated Diseases	Ms
Interactions	AUTOPHAGY, CANCER, CTSD, GLA, GPR37, LRRK2
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GALC — AlphaFold P54803 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GALC["GALC"]
    Als{"Als"}
    GALC -->|"activates"| Als
    Ms{"Ms"}
    GALC -->|"interacts with"| Ms
    Cancer{"Cancer"}
    GALC -->|"activates"| Cancer
    Tumor{"Tumor"}
    GALC -->|"activates"| Tumor
    RAC1["RAC1"]
    GALC -->|"activates"| RAC1
    PSAP["PSAP"]
    GALC -->|"interacts with"| PSAP
    CANCER["CANCER"]
    GALC -->|"activates"| CANCER
    GPR37["GPR37"]
    GALC -->|"activates"| GPR37
    SMAD4["SMAD4"]
    GALC -->|"activates"| SMAD4
    AUTOPHAGY["AUTOPHAGY"]
    GALC -->|"interacts with"| AUTOPHAGY
    CTSD["CTSD"]
    GALC -->|"interacts with"| CTSD
    Autophagy(["Autophagy"])
    GALC -->|"interacts with"| Autophagy
    style GALC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GALC	data_in	dataset_row	0.00
Krabbe disease	causes	disease	0.95
Ms	causes	disease	0.65
Als	activates	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
RAC1	activates	gene	0.60
PSAP	interacts_with	gene	0.60
GPR37	activates	gene	0.60
SMAD4	activates	gene	0.60
CTSD	interacts_with	gene	0.60
CANCER	activates	gene	0.60
PLP1	causes	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Tgf-Β	activates	pathway	0.60
Parkinson's disease	interacts_with	disease	0.60
Sphingolipid	contributes_to	pathway	0.60
Lipid Metabolism	contributes_to	pathway	0.60
OLIGODENDROCYTE	causes	gene	0.60
GENES	causes	gene	0.60
MICROGLIA	causes	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
MYELIN	causes	gene	0.60
MICROGLIA ACTIVATION	causes	gene	0.60
lipid metabolism	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
CRISPR-Cas	participates_in	pathway	0.60
ASTROCYTE	causes	gene	0.60
Autophagy	contributes_to	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
AND	causes	gene	0.60
PSAP	contributes_to	gene	0.60
GLA	inhibits	gene	0.60
LRRK2	inhibits	gene	0.60
neurons	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GALC	data_in	dataset_row	0.00
MYELIN	contributes_to	gene	0.60
GFAP	causes	gene	0.60
ARSA	associated_with	gene	0.60
GLA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GALC in their description or question text

No additional research found