| Gene Symbol | DAGLA |
| Full Name | Diacylglycerol Lipase Alpha |
| Chromosome | 11 |
| Protein Type | Gene |
| Function | is a membrane-bound enzyme that catalyzes the hydrolysis of diacylglycerol (DAG) to produce 2-arachidonoylglycerol (2-AG), one of the most abundant endocannabinoids in the brain[@zhang2018]. |
| Amino Acids | 1042 aa |
| GeneCards | DAGLA |
| Human Protein Atlas | DAGLA |
| N-terminal transmembrane region | Anchors the enzyme to the endoplasmic reticulum membrane |
| Serine hydrolase domain | Contains the catalytic triad (Ser-Asp-His) essential for enzymatic activity |
| Lipase motif (GXSXG) | Critical for diacylglycerol hydrolysis |
| Cerebellum | Highest expression, particularly in Purkinje cells |
| Basal Ganglia | Striatum, substantia nigra pars compacta, globus pallidus |
| Hippocampus | CA1-CA3 pyramidal neurons, dentate gyrus granule cells |
| Cortex | Layer 2/3 pyramidal neurons |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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