protein 773 words KG: GLAPROTEIN
Contents

Alpha-Galactosidase A (GLA Protein)

🔬 Protein Info
Gene SymbolGLAPROTEIN
Protein TypeHydrolase
Functionis a lysosomal hydrolase that cleaves terminal alpha-galactosyl residues from glycolipids and glycoproteins.
Subcellular Localization** | Lysosome |
Molecular Weight46 kDa
GeneCardsGLAPROTEIN
Human Protein AtlasGLAPROTEIN
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Cardiovascular
Known Drugs/Compoundsrapamycin
InteractionsAR, ATG, ATG10, ATG12, ATP6AP2, CALCINEURIN
KG Connections278 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Cryptic Exon Silencing Restoration
Score: 0.53
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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