concept

CGAS-STING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS-STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1489Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CGAS-STING is a concept in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 584 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CGAS-STING
Key Genes/Proteins	Actin, AGING, AIM2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt, Amyloid

Pathway Diagram

graph TD
    CGAS_STING["CGAS-STING"]
    CGAS_STING -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    CGAS_STING -->|"interacts"| Alzheimer["Alzheimer"]
    CGAS_STING -->|"interacts"| Multiple_Sclerosis["Multiple Sclerosis"]
    CGAS_STING -->|"interacts"| Huntington["Huntington"]
    CGAS_STING -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CGAS_STING -->|"activates"| Parkinson["Parkinson"]
    CGAS_STING -->|"activates"| Ataxia["Ataxia"]
    CGAS_STING -->|"activates"| Als["Als"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| CGAS_STING
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| CGAS_STING
    CANCER["CANCER"] -->|"target for"| CGAS_STING
    MICROGLIA["MICROGLIA"] -->|"regulates"| CGAS_STING
    MTOR["MTOR"] -->|"activates"| CGAS_STING
    TBK1["TBK1"] -->|"activates"| CGAS_STING
    MITF["MITF"] -->|"activates"| CGAS_STING

Outgoing (682)

Target	Relation	Type	Str
Als	regulates	disease	1.00
Als	inhibits	disease	1.00
Inflammation	inhibits	disease	1.00
Senescence	activates	disease	1.00
Innate Immunity	regulates	pathway	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Immune Response	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Inflammation	activates	disease	1.00
Infection	activates	disease	1.00
Tumor	activates	disease	1.00
IFN	activates	gene	1.00
Inflammation	therapeutic_target	disease	0.95
Autoimmune	activates	disease	0.95
Glioblastoma Multiforme	targets	disease	0.95
Neuroinflammation	activates	disease	0.95
TFEB	activates	protein	0.95
Inflammation	regulates	disease	0.95
Noncanonical Autophagy	activates	process	0.95
NEUROINFLAMMATION	causes	gene	0.95
NEURODEGENERATION	associated_with	gene	0.95
Neurodegeneration	associated_with	process	0.95
Neuroinflammation	associated_with	process	0.95
Neuroinflammation	associated_with	process	0.95
Lysosome Biogenesis	upregulates	process	0.95
Neurodegeneration	associated_with	process	0.95
Sterile Inflammation	activates	process	0.92
NEUROINFLAMMATION	mediates	process	0.92
Type I Interferon Response	activates	process	0.91
NEURODEGENERATION	involved_in	process	0.90
Ageing-Related Inflammation	associated_with	process	0.90
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.90
Pathogen Clearance	associated_with	process	0.90
Myocardial Ischemia-Reperfusion Injury	causes	disease	0.90
Intracellular DNA Sensing	mediates	process	0.90
Intracellular Dna Sensing	mediates	mechanism	0.90
ALS	contributes_to	disease	0.90
Immune Response	involved_in	process	0.90
PARKINSON'S DISEASE	contributes_to	disease	0.90
Ectopic Dna Detection	involved_in	process	0.90
neural stem cells	active_in	cell_type	0.90
SREBP	regulates	protein	0.90
unfolded protein response	crosstalk_with	pathway	0.90
neurons	active_in	cell_type	0.90
Immune Response	activates	process	0.90
inflammatory signaling	activates	pathway	0.90
Immune Response	associated_with	process	0.90
neurodegenerative diseases	associated_with	disease	0.90
Tau-related pathology	mediates	phenotype	0.90

Incoming (807)

Source	Relation	Type	Str
DNA	activates	gene	1.00
STING	activates	gene	1.00
GENES	activates	gene	1.00
CGAS	activates	gene	1.00
CGAS	associated_with	gene	1.00
IRF3	activates	gene	1.00
TBK1	activates	gene	1.00
CGAS	inhibits	gene	1.00
STING	inhibits	gene	1.00
MTDNA	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
DSDNA	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
STING	associated_with	gene	1.00
CGAS	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
STING	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
DNA	regulates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
Substance P	inhibits	entity	0.95
Mitochondrial Dna	activates	biomarker	0.90
TCe6@Cu/TP5 NPs	activates	compound	0.90
Damaged mitochondria	activates	organelle	0.90
HSV-1	activates	pathway	0.90
STING	participates_in	gene	0.90
FGF21	inhibits	protein	0.90
IFN	participates_in	gene	0.90
DNA	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
aging	involves	disease	0.90
neurodegeneration	involves	disease	0.90
Alzheimer's disease	involves	disease	0.90
CGAS	regulates	gene	0.90
STING	regulates	gene	0.90
DNA	associated_with	gene	0.90
PYROPTOSIS	activates	gene	0.90
NF-ΚB	activates	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
UFMylation	inhibits	process	0.87
Cgas Inhibitors	inhibits	drug	0.85
Impaired mitophagy	activates	process	0.85
IFN	activates	gene	0.80
CGAS	participates_in	gene	0.80
TBK1	participates_in	gene	0.80
TDP-43	triggers	protein	0.80
RU.521	inhibits	compound	0.80
NLRP3	participates_in	gene	0.80
H-151	inhibits	compound	0.80
CYTOSOLIC DNA BUILDUP	activates	process	0.80

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
cGAS-STING Senescence Circuit Disruption	0.691	neurodegeneration	Gene expression changes in aging mouse b
Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta	0.560	neuroinflammation	How does chronic cGAS/STING activation d
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gap 006 analysis (archived stub)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251]	Tomaskovic I, Prieto-Garcia C, Boskovic	Science	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026
STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053]	Ye R, Wang S, Hu Y, Pan Y, Zheng W et al	Science	2026
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164]	Unknown		2025
The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238]	Unknown		2025
Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133]	Hyde VR, Zhou C, Fernandez JR, Chatterje	Cell reports	2025
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433]	Carling GK, Fan L, Foxe NR, Norman K, Wo	Neuron	2024
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623]	["Jin Meihua", "Shiwaku Hiroki", "Tanaka	Nature communications	2021

Debates (1)

Multi-agent debates referencing this entity

Analysis for knowledge gap 006 in the neurodegeneration domain.

closed · Rounds: 4 · Score: 0.79 · 2026-04-22

Related Research

Hypotheses and analyses mentioning CGAS-STING in their description or question text

No additional research found