gene 2,204 words KG: FOXP3
Contents

FOXP3 (Forkhead Box P3)

🧬 Gene Info
Gene SymbolFOXP3
Full NameFOXP3 (Forkhead Box P3)
ChromosomeXp11.23
Protein TypeTranscription Factor
Target ClassTranscription Factor
FunctionTranscription factor modulation - no direct small molecule binding
Mechanism of ActionTranscription factor modulation - no direct small molecule binding
DruggabilityLow (0.35)
Clinical StagePhase I
Amino Acids431 aa
PathwaysApoptosis, Complement, Hedgehog, Immune Response, Mtor
UniProt IDA0A494BZV0
GeneCardsFOXP3
Human Protein AtlasFOXP3
Associated DiseasesAls, Alzheimer, Autoimmune, cancer
Known Drugs/Compoundspaeoniflorin, Paeoniflorin
InteractionsACHE, ACOD1, AIF1, AKT, AMPK, AND
SciDEX TargetView Target Profile (2 clinical trials)
KG Connections568 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Ocular Immune Privilege Extension
Score: 0.69
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
APOE-Dependent Autophagy Restoration
Score: 0.88
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
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Related Analyses (8)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: associated_with
ATM Gene
gene · KG edge: expressed_in
BAX Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FOXP3 interacts_with TGFB1
TGFB1 interacts_with FOXP3
FOXP3 co_discussed TNFA
FOXP3 co_discussed PPARGC1A
FOXP3 co_discussed PRKAA1
FOXP3 co_discussed NR3C1
FOXP3 co_discussed DRD2
FOXP3 co_discussed CHR2
FOXP3 co_discussed CLOCK
FOXP3 co_discussed CRH

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