gene

RORA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RORA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

RORA (Retinoic Acid Receptor-Related Orphan Receptor Alpha) is a nuclear receptor that plays critical roles in circadian rhythm regulation, cerebellar development, and has been implicated in neurodegenerative diseases including Alzheimer's, Parkinson's, and ataxia.

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🧬 Gene Info

Gene Symbol	RORA
Full Name	RAR Related Orphan Receptor A
Protein Type	Receptor
Function	is a member of the nuclear receptor superfamily that functions as a transcriptional activator in the circadian clock machinery.
Primary Expression	Prefrontal Cortex, Cortex
Pathways	Autophagy, Notch, Metastasis, Chemoresistance, Apoptosis
GeneCards	RORA
Human Protein Atlas	RORA
N-terminal activation domain (AF-1)	Responsible for transcriptional activation and protein-protein interactions
DNA-binding domain (DBD)	Contains two zinc-finger motifs that recognize specific DNA sequences
Hinge region	Provides flexibility and contains the ligand-binding domain
Ligand-binding domain (LBD)	Contains the AF-2 activation function and mediates interactions with co-regulators
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, App, APP
KG Connections	124 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RORA — RAR Related Orphan Receptor A

gene · 1992 words

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Pathway Diagram

graph TD
    RORA["RORA"]
    Als{"Als"}
    RORA -->|"activates"| Als
    Hepatitis{"Hepatitis"}
    RORA -->|"associated with"| Hepatitis
    Glioblastoma{"Glioblastoma"}
    RORA -->|"associated with"| Glioblastoma
    Alzheimer{"Alzheimer"}
    RORA -->|"associated with"| Alzheimer
    Obesity{"Obesity"}
    RORA -->|"associated with"| Obesity
    Diabetes{"Diabetes"}
    RORA -->|"associated with"| Diabetes
    Stroke{"Stroke"}
    RORA -->|"associated with"| Stroke
    Multiple_Sclerosis{"Multiple Sclerosis"}
    RORA -->|"associated with"| Multiple_Sclerosis
    RORA -->|"associated with"| Als
    Cancer{"Cancer"}
    RORA -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    RORA -->|"associated with"| Carcinoma
    Fibrosis{"Fibrosis"}
    RORA -->|"associated with"| Fibrosis
    BECN1["BECN1"]
    BECN1 -->|"activates"| RORA
    style RORA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
Als	treats	disease	0.65
Cancer	treats	disease	0.65
Ovarian Cancer	treats	disease	0.65
Als	expressed_in	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Notch	associated_with	pathway	0.60
FGF14	activates	gene	0.60
GRIN2A	activates	gene	0.60
NLGN1	activates	gene	0.60
KCNIP4	activates	gene	0.60
NRXN1	activates	gene	0.60
CANCER	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
Actin	activates	protein	0.60
LC3	activates	gene	0.60
Metastasis	treats	pathway	0.60
Chemoresistance	treats	pathway	0.60
Neuron	activates	cell_type	0.60
SQSTM1	activates	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
RORB	activates	gene	0.60
APP	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
IFN	associated_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
SYNAPSE	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60

Incoming (38)

Source	Relation	Type	Str
WTAP	expressed_in	gene	0.60
BECN1	activates	gene	0.60
TP53	treats	gene	0.60
E2F2	interacts_with	gene	0.60
E2F4	interacts_with	gene	0.60
GAIN	expressed_in	gene	0.60
LAMP3	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
IRF3	activates	gene	0.60
NGF	activates	gene	0.60
PERK	activates	gene	0.60
GRIN2A	activates	gene	0.60
FGF14	activates	gene	0.60
NR1D2	associated_with	gene	0.60
CKAP4	associated_with	gene	0.60
NRXN1	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
CANCER	treats	gene	0.60
CREB	activates	gene	0.60
ERBB2	activates	gene	0.60
IFN	activates	gene	0.60
NLGN1	activates	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.50
GENES	interacts_with	gene	0.50
NEURON	co_discussed	gene	0.50
GRIN2A	co_discussed	gene	0.50
NCAM2	co_discussed	gene	0.50
NRXN1	co_discussed	protein	0.50
RORB	activates	gene	0.50
late	activates	disease	0.50
NRXN1	co_expressed_with	protein	0.50
NRG3	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RORA in their description or question text

No additional research found