gene

BMP7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

46Outgoing

16Incoming

0Experiments

0Debates

Summary

TGF-beta superfamily member with neuroprotective properties in Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	BMP7
Function	encodes a member of the TGF-beta superfamily of signaling molecules.
Primary Expression	adult tissues and has important roles in bone formation, kidney development, tissue repair, and neuroprotection
Amino Acids	431 aa
Pathways	MAPK pathway, PI3K
Ensembl ID	ENSG00000101144
GeneCards	BMP7
Human Protein Atlas	BMP7
Precursor protein	~431 amino acids
Signal peptide	N-terminal targeting sequence
Prodomain	Removed during processing
Mature dimer	Active form (~115 amino acids per monomer)
Homodimers	Most common active form
Heterodimers	Can pair with BMP2 or BMP4 for enhanced activity
Disulfide bonds	Cysteine-mediated dimerization
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Interactions	AND, BMP4, BMPR1B, ERK, ERK1, TGFB2
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BMP7 Gene (Bone Morphogenetic Protein 7)

gene · 1147 words

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Pathway Diagram

graph TD
    BMP7["BMP7"]
    Ms{"Ms"}
    BMP7 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    BMP7 -->|"activates"| Tumor
    Carcinoma{"Carcinoma"}
    BMP7 -->|"associated with"| Carcinoma
    BMP7 -->|"associated with"| Ms
    Cancer{"Cancer"}
    BMP7 -->|"associated with"| Cancer
    BMP7 -->|"associated with"| Tumor
    Hepatitis{"Hepatitis"}
    BMP7 -->|"associated with"| Hepatitis
    Glioblastoma{"Glioblastoma"}
    BMP7 -->|"associated with"| Glioblastoma
    Alzheimer{"Alzheimer"}
    BMP7 -->|"associated with"| Alzheimer
    Obesity{"Obesity"}
    BMP7 -->|"associated with"| Obesity
    Diabetes{"Diabetes"}
    BMP7 -->|"associated with"| Diabetes
    Stroke{"Stroke"}
    BMP7 -->|"associated with"| Stroke
    ERK["ERK"]
    ERK -->|"activates"| BMP7
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| BMP7
    BMP4["BMP4"]
    BMP4 -->|"activates"| BMP7
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| BMP7
    MYC["MYC"]
    MYC -->|"associated with"| BMP7
    E2F5["E2F5"]
    E2F5 -->|"associated with"| BMP7
    CDKN2B["CDKN2B"]
    CDKN2B -->|"associated with"| BMP7
    TGFBR1["TGFBR1"]
    TGFBR1 -->|"activates"| BMP7
    CANCER["CANCER"]
    CANCER -->|"associated with"| BMP7
    BMP2["BMP2"]
    BMP2 -->|"associated with"| BMP7
    TGFB2["TGFB2"]
    TGFB2 -->|"activates"| BMP7
    RORA["RORA"]
    RORA -->|"associated with"| BMP7
    style BMP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Astrocyte	regulates	cell_type	0.80
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Obesity	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
AHR	associated_with	gene	0.60
EP300	associated_with	gene	0.60
JUN	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
CCL20	associated_with	gene	0.60
CD38	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NOTCH1	associated_with	gene	0.60
SMAD6	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
GATA3	associated_with	gene	0.60
ATF6	associated_with	gene	0.60
MAF	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
Notch	associated_with	pathway	0.60
TGFB2	activates	gene	0.60
Differentiation	inhibits	pathway	0.60
E2F5	associated_with	gene	0.60

Incoming (16)

Source	Relation	Type	Str
TGFBR2	associated_with	gene	0.60
BMP4	activates	gene	0.60
MYC	associated_with	gene	0.60
E2F5	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
TGFBR1	activates	gene	0.60
BMP2	associated_with	gene	0.60
TGFB2	activates	gene	0.60
ERK1	inhibits	gene	0.60
BMPR1B	activates	gene	0.60
ERK	activates	gene	0.60
RORA	associated_with	gene	0.60
ERK	inhibits	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BMP7 in their description or question text

No additional research found