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protein 1,324 words KG: FASNPROTEIN
Contents

FASN Protein

🔬 Protein Info
Gene SymbolFASN
AliasesFASNPROTEIN
Chromosome1q25
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization** | Cytoplasm, Cytosolic |
Molecular Weight273 kDa
PathwaysAkt, Lipid Metabolism, Mtor, Pi3K
Ensembl IDENSG00000169710
GeneCardsFASN
Human Protein AtlasFASN
Associated DiseasesAD, Aging, AMI, ARM, Atherosclerosis, breast cancer
InteractionsABCA1, ACACA, ACC, ACLY, ACOX1, ACSL4
KG Connections354 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72APOE-Dependent Autophagy Restoration
Score: 0.85Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_innct05508789
clinical_trial · Pages share 4 hypothesesMK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypothesesA Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

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