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gene 1,282 words KG: FASN
Contents

FASN Gene

🧬 Gene Info
Gene SymbolFASN
Chromosome1q25
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight273 kDa
PathwaysAkt, Lipid Metabolism, Mtor, Pi3K
Ensembl IDENSG00000169710
GeneCardsFASN
Human Protein AtlasFASN
Associated DiseasesAD, Aging, AMI, ARM, Atherosclerosis, breast cancer
InteractionsABCA1, ACACA, ACC, ACLY, ACOX1, ACSL4
KG Connections352 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Circadian Clock-Autophagy Synchronization
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Membrane Cholesterol Gradient Modulators
Score: 0.71Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
pg 1/2Next →

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Microglia activate astroc
falsification · completed · Score: 0.40

See Also (15)

ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibitsAccelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_inApoptosis in Neurodegeneration
entity · KG edge: activatesALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: expressed_in

Knowledge Graph (12 edges)

PRMT1 activates FASN
FASN activates SRC
FASN activates HK1
FASN activates MTOR
FASN activates PTEN
FASN activates HK2
FASN inhibits BAX
FASN inhibits ALOX15
FASN inhibits GSDMD
FASN inhibits SCD1

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