disease

HEPATOCELLULAR CARCINOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEPATOCELLULAR CARCINOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

927Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	EXOSOMES, LRP1, MTOR, NF-KB, RAB7A, SLC7A11, TGF-BETA
KG Connections	201 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"associated"| METASTASIS["METASTASIS"]
    style METASTASIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"activates"| NF_KB["NF-KB"]
    style NF_KB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"activates"| AKT["AKT"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"expressed in"| T_CELLS["T CELLS"]
    style T_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"regulates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"] -->|"regulates"| TGF_BETA["TGF-BETA"]
    style TGF_BETA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CELL_PROLIFERATION["CELL PROLIFERATION"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style CELL_PROLIFERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AUTOPHAGY["AUTOPHAGY"] -.->|"inhibits"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    METASTASIS_1["METASTASIS"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style METASTASIS_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TGF_BETA_2["TGF-BETA"] -->|"associated"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style TGF_BETA_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NF_KB_3["NF-KB"] -.->|"inhibits"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style NF_KB_3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style HEPATOCELLULAR_CARCINOMA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (307)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Carcinoma	associated_with	disease	1.00
Ferroptosis	activates	pathway	1.00
Cancer	associated_with	disease	1.00
Carcinoma	activates	disease	1.00
Cancer	activates	disease	1.00
Autophagy	activates	pathway	1.00
Cancer	causes	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
Liver Cancer	associated_with	disease	0.95
Carcinoma	causes	disease	0.95
Genomic Characterization	associated_with	process	0.95
Liver Cancer	therapeutic_target	disease	0.95
Hepatitis	associated_with	disease	0.95
Multimodal Tumor Thermal Therapy	therapeutic_target	process	0.95
Integrative Analysis	associated_with	process	0.90
Cancer Genome	biomarker_for	biomarker	0.90
Mtor	activates	pathway	0.90
Metastasis	activates	pathway	0.90
Pi3K/Akt	activates	pathway	0.90
Angiogenesis	involved_in	process	0.85
Inflammation	activates	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Glycolysis	activates	pathway	0.80
Lipid Metabolism	therapeutic_target	pathway	0.80
Autophagy	associated_with	pathway	0.80
Apoptosis	activates	pathway	0.80
Er Stress	activates	pathway	0.80
Als	inhibits	disease	0.75
Als	causes	disease	0.75
Nafld	therapeutic_target	disease	0.75
Fatty Liver	therapeutic_target	disease	0.75
Carcinoma	inhibits	disease	0.75
Cancer	inhibits	disease	0.75
Hepatitis	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Epigenetic	treats	pathway	0.70
Metastasis	inhibits	pathway	0.70
Mtor	treats	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Drug Resistance	therapeutic_target	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Glycolysis	inhibits	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Tgf-Β	therapeutic_target	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Cholesterol	therapeutic_target	pathway	0.70
Wnt	therapeutic_target	pathway	0.70

Incoming (620)

Source	Relation	Type	Str
Carcinoma	associated_with	disease	1.00
Cancer	activates	disease	1.00
AKT	activates	gene	1.00
GENES	activates	gene	1.00
FERROPTOSIS	activates	gene	1.00
PI3K	activates	gene	1.00
Tumor	associated_with	disease	1.00
CANCER	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Carcinoma	activates	disease	1.00
Tumor	activates	disease	1.00
Tumor	inhibits	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
CANCER	causes	gene	1.00
TMX2	associated_with	gene	0.95
Cx3Cr1+Gpr56+ T Cells	biomarker_for	cell_type	0.95
Lactate	promotes	compound	0.95
Britannin	inhibits	compound	0.95
STAT3	activates	gene	0.95
STAT3	therapeutic_target	gene	0.95
P62	activates	gene	0.95
NUPR1	therapeutic_target	gene	0.95
GPC3	biomarker_for	biomarker	0.95
AFP	biomarker_for	biomarker	0.95
Nash	causes	disease	0.95
PTEN	activates	gene	0.95
NRF2	activates	gene	0.95
Nafld	contributes_to	disease	0.95
PI3K/AKT/mTOR Signaling	regulates	pathway	0.95
KEAP1	activates	gene	0.95
INFLAMMATION	activates	gene	0.95
UBIQUITIN	activates	gene	0.95
DCP	biomarker_for	biomarker	0.95
CANCER	therapeutic_target	gene	0.95
Catenibacterium mitsuokai	promotes	organism	0.95
Lactate	causes	compound	0.95
Cancer Genome Atlas Research Network	involved_in	process	0.95
Central Nervous System	modulates	process	0.95
Peripheral Nervous System	modulates	process	0.95
Genomic Alterations	associated_with	mechanism	0.95
FDX1	downregulates	gene	0.95
TGM2	promotes	protein	0.92
HDAC2	associated_with	gene	0.92
TMX2	promotes	protein	0.90
Tumor Suppressor Genes	associated_with	mechanism	0.90
FDX1	protects_against	gene	0.90
AKR1B10	promotes	gene	0.90
mitophagy	therapeutic_target	process	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity