gene 1,033 words KG: FAM134B
Contents

FAM134B — Family With Sequence Similarity 134 Member B

🧬 Gene Info
Gene SymbolFAM134B
Full NameFamily With Sequence Similarity 134 Member B
Chromosome5
Protein TypeReceptor
Functionis a critical ER-phagy receptor protein that plays an essential role in endoplasmic reticulum quality control and turnover.
Primary ExpressionNeurons, peripheral sensory neurons
Amino Acids476 aa
PathwaysAutophagy, Innate Immunity
UniProt IDQ9H6Y3
NCBI Gene ID54494
Ensembl IDENSG00000144136
OMIM613374
GeneCardsFAM134B
Human Protein AtlasFAM134B
Bandp15.1
Associated DiseasesAD, ALI, Als, Alzheimer, dementia
InteractionsABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections478 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
APOE-Dependent Autophagy Restoration
Score: 0.88
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
RNA Granule Nucleation Site Modulation
Score: 0.66

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CAT interacts_with FAM134B
OPTN interacts_with FAM134B
DNM1L interacts_with FAM134B
CANX interacts_with FAM134B
LGALS3 interacts_with FAM134B
CALCOCO2 interacts_with FAM134B
G3BP1 interacts_with FAM134B
PEX3 interacts_with FAM134B
SQSTM1 interacts_with FAM134B
BCL2 interacts_with FAM134B

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