gene

CPT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

0Experiments

0Debates

Summary

Carnitine Palmitoyltransferase 2 - mitochondrial enzyme critical for fatty acid beta-oxidation, with links to neurodegenerative diseases including Alzheimer's, Parkinson's, and Huntington's disease

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🧬 Gene Info

Gene Symbol	CPT2
Aliases	Carnitine Palmitoyltransferase 2
Chromosome	1p32.3
Protein Type	Enzyme
Function	encodes a mitochondrial enzyme that catalyzes the conversion of acylcarnitine esters back to free carnitine and fatty acyl-CoA esters.
Amino Acids	659 aa
Pathways	Amyloid, Lipid Metabolism, Mitochondrial Function, Oxidative Phosphorylation
Ensembl ID	ENSG00000157184
GeneCards	CPT2
Human Protein Atlas	CPT2
Transmembrane anchor	A single transmembrane helix that localizes the protein to the inner mitochondrial membrane
Catalytic domain	The bulk of the protein faces the mitochondrial matrix where catalysis occurs
Substrate binding pocket	Contains residues for carnitine and acyl-CoA binding
Associated Diseases	Als, Cancer, Cardiac, Heart Failure, Tumor
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-Β PLAQUES, AND, CANCER
KG Connections	73 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CPT2

gene · 1391 words

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Pathway Diagram

graph TD
    CPT2["CPT2"]
    Ms{"Ms"}
    CPT2 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    CPT2 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    CPT2 -->|"inhibits"| Tumor
    CANCER["CANCER"]
    CPT2 -->|"inhibits"| CANCER
    SLC44A2["SLC44A2"]
    CPT2 -->|"inhibits"| SLC44A2
    MUL1["MUL1"]
    CPT2 -->|"activates"| MUL1
    neurodegeneration["neurodegeneration"]
    CPT2 -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| CPT2
    style CPT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Cardiac	implicated_in	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Heart Failure	implicated_in	disease	0.65
Mitophagy	inhibits	pathway	0.60
MITOCHONDRIA	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Ras	activates	protein	0.60
ALZHEIMER	activates	gene	0.60
MICROGLIA	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
Mitochondrial Function	activates	pathway	0.60
Oligodendrocyte	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
AND	activates	gene	0.60
AMYLOID-Β PLAQUES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
IDH2	activates	gene	0.60
TAU	activates	gene	0.60
GENES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
CPT1A	associated_with	gene	0.60
SLC44A2	inhibits	gene	0.60
MUL1	activates	gene	0.60
USP30	implicated_in	gene	0.60
PARKIN	implicated_in	gene	0.60
HSPA1A	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Amyloid	activates	pathway	0.60
CACNA2D2	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Oligodendrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
NEURON	co_discussed	gene	0.50
SST	activates	gene	0.50
GENES	co_discussed	gene	0.50

Incoming (21)

Source	Relation	Type	Str
UBIQUITIN	activates	gene	0.60
MICROGLIA	activates	gene	0.60
IDH2	activates	gene	0.60
SST	activates	gene	0.60
PVALB	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
PINK1	implicated_in	gene	0.60
PARL	implicated_in	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
CACNB3	associated_with	gene	0.60
ADRB1	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
HDAC3	associated_with	gene	0.60
CRYAB	associated_with	gene	0.60
AND	associated_with	gene	0.60
CDH1	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
TAU	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CPT2 in their description or question text

No additional research found