Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CACNB3 |
| Protein Type | Gene |
| Function | is a hallmark across AD, PD, and FTD spectra. |
| Molecular Weight | 66 kDa |
| Pathways | MAPK, mapk, PI3K, mTOR |
| GeneCards | CACNB3 |
| Human Protein Atlas | CACNB3 |
| Associated Diseases | Mesial Temporal Lobe Epilepsy |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CACNB3"]
N1["Plasma membrane"]
N0 -->|"associated with"| N1
N2["Ca(v)1.4"]
N0 -->|"associated with"| N2
N3["Kir/Gem"]
N0 -->|"binds"| N3
N4["Mesial Temporal Lobe Epilepsy"]
N0 -->|"associated with"| N4
N5["Blood-Brain Barrier"]
N0 -->|"associated with"| N5
N6["Insulin Expression"]
N0 -->|"regulates"| N6
N7["CACNA1C"]
N0 -->|"participates in"| N7
N8["hsa-miR-34a-5p"]
N8 -->|"regulates"| N0
N9["ADRB1"]
N0 -->|"associated with"| N9
N10["AGING"]
N0 -->|"therapeutic target"| N10
N11["CPT2"]
N0 -->|"associated with"| N11
N12["CPT1A"]
N0 -->|"associated with"| N12
N13["CACNA2D2"]
N0 -->|"associated with"| N13
N14["Rb"]
N0 -->|"associated with"| N14
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N2 protein
class N3 protein
class N4 disease
class N7 protein
class N9 gene
class N10 gene
class N11 gene
class N12 gene
class N13 gene
class N14 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Plasma membrane | associated_with | entity | 0.90 |
| Ca(v)1.4 | associated_with | protein | 0.80 |
| Kir/Gem | binds | protein | 0.80 |
| Mesial Temporal Lobe Epilepsy | associated_with | disease | 0.80 |
| Insulin Expression | regulates | process | 0.80 |
| CACNA1C | participates_in | protein | 0.70 |
| ADRB1 | associated_with | gene | 0.60 |
| CPT2 | associated_with | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| CPT1A | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| hsa-miR-34a-5p | regulates | entity | 0.70 |
| CDH1 | therapeutic_target | gene | 0.60 |
| PER | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CACNB3 in their description or question text
No additional research found