Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG1 (ULK1 in mammals) |
| Full Name | Unc-51 Like Autophagy Activating Kinase 1 |
| Aliases | ATG1, atg1 |
| Chromosome | 12q13.12 |
| Protein Type | Serine/Threonine Kinase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | ~105 kDa |
| Pathways | Exocytosis |
| UniProt ID | [Q9Y4P5](https://www.uniprot.org/uniprot/Q9Y4P5) |
| ULK1 | Catalytic serine/threonine kinase that initiates autophagy signaling |
| ATG13 | Regulatory subunit that enhances ULK1 activity and serves as a scaffold |
| FIP200 | Scaffold protein that recruits downstream effectors |
| ATG101 | Stabilizing subunit that protects ATG13 from degradation |
| Associated Diseases | Ataxia, Neurodegeneration |
| Interactions | AMPK, AND, ATG, ATG13, ATG5, AUTOPHAGY |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATG1["ATG1"] -->|"activates"| Als["Als"]
style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATG1["ATG1"] -->|"activates"| Ms["Ms"]
style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATG1["ATG1"] -->|"implicated in"| Ataxia["Ataxia"]
style Ataxia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATG1["ATG1"] -->|"implicated in"| Neurodegeneration["Neurodegeneration"]
style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ATG1["ATG1"] -->|"associated"| ULK2["ULK2"]
style ULK2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ATG1["ATG1"] -->|"activates"| ULK1["ULK1"]
style ULK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ATG1["ATG1"] -->|"activates"| Mitophagy["Mitophagy"]
style Mitophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
ATG["ATG"] -->|"component of"| ATG1["ATG1"]
style ATG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ULK1_1["ULK1"] -->|"co expressed with"| ATG1["ATG1"]
style ULK1_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
AMPK["AMPK"] -->|"associated"| ATG1["ATG1"]
style AMPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
MITOPHAGY["MITOPHAGY"] -->|"activates"| ATG1["ATG1"]
style MITOPHAGY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
P62["P62"] -->|"activates"| ATG1["ATG1"]
style P62 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style ATG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.75 |
| Ms | activates | disease | 0.65 |
| Ataxia | implicated_in | disease | 0.65 |
| Neurodegeneration | implicated_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| MICROTUBULES | regulates | gene | 0.60 |
| ATG9 | associated_with | gene | 0.60 |
| Exocytosis | regulates | pathway | 0.60 |
| T Cell | activates | cell_type | 0.60 |
| ULK2 | associated_with | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| ATG13 | interacts_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ATG | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Pi3K | interacts_with | pathway | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| SCA3 | implicated_in | gene | 0.60 |
| RAB7 | implicated_in | gene | 0.60 |
| ATG12 | regulates | gene | 0.60 |
| ULK1 | regulates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| ULK1 | associated_with | entity | 0.60 |
| ATG5 | associated_with | gene | 0.60 |
| CLN5 | associated_with | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| mitophagy | activates | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATG | component_of | gene | 0.80 |
| ULK1 | co_expressed_with | protein | 0.75 |
| AMPK | associated_with | gene | 0.60 |
| ATG5 | regulates | gene | 0.60 |
| RAB5 | implicated_in | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| ULK2 | associated_with | gene | 0.60 |
| ENDOSOME | implicated_in | gene | 0.60 |
| NEURODEGENERATION | implicated_in | gene | 0.60 |
| ENDOSOMES | implicated_in | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ULK1 | regulates | gene | 0.60 |
| LYST | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATG1 in their description or question text
No additional research found